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MeSH Review

Leukemia, Myeloid

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Disease relevance of Leukemia, Myeloid


Psychiatry related information on Leukemia, Myeloid


High impact information on Leukemia, Myeloid


Chemical compound and disease context of Leukemia, Myeloid

  • About 65 percent of previously untreated adults with primary acute myeloid leukemia (AML) enter complete remission when treated with cytarabine and an anthracycline [13].
  • To determine the clinical importance of this property, we measured the uptake of tritiated thymidine by leukemic cells in serum-free and cytokine-free cultures as a means of determining the rate of spontaneous proliferation in 114 patients with newly diagnosed acute myeloid leukemia [14].
  • The results genetically define a connection between the Bcr-Abl cytoplasmic tyrosine kinase and Ras and add to the accumulating evidence that deregulation of Ras is a central event in the genesis of a number of molecularly distinct forms of human myeloid leukemia [15].
  • Taken together, these results demonstrate that in vivo activation of cAMP signaling contributes to APL clearance, independently of its RA-sensitivity, thus raising hopes that other myeloid leukemias may benefit from this therapeutic approach [16].
  • Ara-C treatment was also associated with increases in c-jun transcripts in U-937, THP-1, and HL-60 myeloid leukemia cells [17].
  • These observations reveal a significant cross-talk between Ca(2+) and retinoic acid signaling pathways that regulates the differentiation of myeloid leukemia cells, and they suggest that CaMKIIgamma may provide a new therapeutic target for the treatment of certain human myeloid leukemias [18].

Biological context of Leukemia, Myeloid


Anatomical context of Leukemia, Myeloid


Gene context of Leukemia, Myeloid

  • In addition, the CD14 gene is included in the "critical" region that is frequently deleted in certain myeloid leukemias [28].
  • One of its components, CAN/Nup214, is an FXFG repeat-containing protein known to be involved in myeloid leukemia in humans [29].
  • ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex [30].
  • In addition, we have identified a third chimeric transcript, AML1/EVI1, in one of the therapy-related acute myeloid leukemia patients [31].
  • Likewise, in murine myeloid leukemia, transcriptional coactivation of Meis1 with HoxA7/A9 suggests that Meis1-HoxA7/9 heterodimers may evoke aberrant gene transcription [32].

Analytical, diagnostic and therapeutic context of Leukemia, Myeloid


  1. Low doses of cytarabine in the treatment of myelodysplastic syndrome and acute myeloid leukemia. Mufti, G.J., Oscier, D.G., Hamblin, T.J., Bell, A.J. N. Engl. J. Med. (1983) [Pubmed]
  2. Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia. Dong, F., Brynes, R.K., Tidow, N., Welte, K., Löwenberg, B., Touw, I.P. N. Engl. J. Med. (1995) [Pubmed]
  3. P-glycoprotein in acute nonlymphoblastic leukemia and in the blastic crisis of myeloid leukemia. Carulli, G., Petrini, M., Marini, A., Ambrogi, F. N. Engl. J. Med. (1988) [Pubmed]
  4. The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. Zhu, Y.X., Benn, S., Li, Z.H., Wei, E., Masih-Khan, E., Trieu, Y., Bali, M., McGlade, C.J., Claudio, J.O., Stewart, A.K. J. Exp. Med. (2004) [Pubmed]
  5. Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Dinarello, C.A., Thompson, R.C. Immunol. Today (1991) [Pubmed]
  6. Conversion disorder with convulsion and motor deficit mimicking the adverse effects of high-dose Ara-C treatment in a posttransplant acute myeloid leukemia patient: a case report and review of the literature. Onishi, H., Kamijo, A., Onose, M., Yamada, T., Mizuno, Y., Ito, M., Saito, H., Maruta, I. Palliative & supportive care. (2004) [Pubmed]
  7. Successful lithium carbonate treatment for steroid-induced depression following bone marrow transplantation: a case report. Ito, M., Onose, M., Yamada, T., Onishi, H., Fujisawa, S., Kanamori, H. Jpn. J. Clin. Oncol. (2003) [Pubmed]
  8. Vitamin D: recent advances. DeLuca, H.F., Schnoes, H.K. Annu. Rev. Biochem. (1983) [Pubmed]
  9. Single cell profiling of potentiated phospho-protein networks in cancer cells. Irish, J.M., Hovland, R., Krutzik, P.O., Perez, O.D., Bruserud, Ø., Gjertsen, B.T., Nolan, G.P. Cell (2004) [Pubmed]
  10. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Tartaglia, M., Niemeyer, C.M., Fragale, A., Song, X., Buechner, J., Jung, A., Hählen, K., Hasle, H., Licht, J.D., Gelb, B.D. Nat. Genet. (2003) [Pubmed]
  11. Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. Cassileth, P.A., Harrington, D.P., Appelbaum, F.R., Lazarus, H.M., Rowe, J.M., Paietta, E., Willman, C., Hurd, D.D., Bennett, J.M., Blume, K.G., Head, D.R., Wiernik, P.H. N. Engl. J. Med. (1998) [Pubmed]
  12. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Nagy, L., Kao, H.Y., Chakravarti, D., Lin, R.J., Hassig, C.A., Ayer, D.E., Schreiber, S.L., Evans, R.M. Cell (1997) [Pubmed]
  13. Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. Mayer, R.J., Davis, R.B., Schiffer, C.A., Berg, D.T., Powell, B.L., Schulman, P., Omura, G.A., Moore, J.O., McIntyre, O.R., Frei, E. N. Engl. J. Med. (1994) [Pubmed]
  14. Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia. Löwenberg, B., van Putten, W.L., Touw, I.P., Delwel, R., Santini, V. N. Engl. J. Med. (1993) [Pubmed]
  15. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. Sawyers, C.L., McLaughlin, J., Witte, O.N. J. Exp. Med. (1995) [Pubmed]
  16. In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia. Guillemin, M.C., Raffoux, E., Vitoux, D., Kogan, S., Soilihi, H., Lallemand-Breitenbach, V., Zhu, J., Janin, A., Daniel, M.T., Gourmel, B., Degos, L., Dombret, H., Lanotte, M., De Thé, H. J. Exp. Med. (2002) [Pubmed]
  17. Transcriptional regulation of c-jun gene expression by arabinofuranosylcytosine in human myeloid leukemia cells. Kharbanda, S.M., Sherman, M.L., Kufe, D.W. J. Clin. Invest. (1990) [Pubmed]
  18. CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells. Si, J., Mueller, L., Collins, S.J. J. Clin. Invest. (2007) [Pubmed]
  19. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Morishita, K., Parker, D.S., Mucenski, M.L., Jenkins, N.A., Copeland, N.G., Ihle, J.N. Cell (1988) [Pubmed]
  20. An RNA polymerase II elongation factor encoded by the human ELL gene. Shilatifard, A., Lane, W.S., Jackson, K.W., Conaway, R.C., Conaway, J.W. Science (1996) [Pubmed]
  21. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Di Leonardo, A., Linke, S.P., Clarkin, K., Wahl, G.M. Genes Dev. (1994) [Pubmed]
  22. Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. Radomska, H.S., Bassères, D.S., Zheng, R., Zhang, P., Dayaram, T., Yamamoto, Y., Sternberg, D.W., Lokker, N., Giese, N.A., Bohlander, S.K., Schnittger, S., Delmotte, M.H., Davis, R.J., Small, D., Hiddemann, W., Gilliland, D.G., Tenen, D.G. J. Exp. Med. (2006) [Pubmed]
  23. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Nguyen, H.Q., Hoffman-Liebermann, B., Liebermann, D.A. Cell (1993) [Pubmed]
  24. Enhancement of cellular accumulation of cyclosporine by anti-P-glycoprotein monoclonal antibody MRK-16 and synergistic modulation of multidrug resistance. Naito, M., Tsuge, H., Kuroko, C., Koyama, T., Tomida, A., Tatsuta, T., Heike, Y., Tsuruo, T. J. Natl. Cancer Inst. (1993) [Pubmed]
  25. Expression of the early growth response 1 and 2 zinc finger genes during induction of monocytic differentiation. Kharbanda, S., Nakamura, T., Stone, R., Hass, R., Bernstein, S., Datta, R., Sukhatme, V.P., Kufe, D. J. Clin. Invest. (1991) [Pubmed]
  26. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. Göttlicher, M., Minucci, S., Zhu, P., Krämer, O.H., Schimpf, A., Giavara, S., Sleeman, J.P., Lo Coco, F., Nervi, C., Pelicci, P.G., Heinzel, T. EMBO J. (2001) [Pubmed]
  27. DNA methylation profiles in the human genes for tumor necrosis factors alpha and beta in subpopulations of leukocytes and in leukemias. Kochanek, S., Radbruch, A., Tesch, H., Renz, D., Doerfler, W. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  28. The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors. Goyert, S.M., Ferrero, E., Rettig, W.J., Yenamandra, A.K., Obata, F., Le Beau, M.M. Science (1988) [Pubmed]
  29. G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214. van Deursen, J., Boer, J., Kasper, L., Grosveld, G. EMBO J. (1996) [Pubmed]
  30. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Wang, J., Hoshino, T., Redner, R.L., Kajigaya, S., Liu, J.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  31. Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations. Nucifora, G., Begy, C.R., Kobayashi, H., Roulston, D., Claxton, D., Pedersen-Bjergaard, J., Parganas, E., Ihle, J.N., Rowley, J.D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  32. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Knoepfler, P.S., Calvo, K.R., Chen, H., Antonarakis, S.E., Kamps, M.P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  33. Ligation of the CD44 adhesion molecule reverses blockage of differentiation in human acute myeloid leukemia. Charrad, R.S., Li, Y., Delpech, B., Balitrand, N., Clay, D., Jasmin, C., Chomienne, C., Smadja-Joffe, F. Nat. Med. (1999) [Pubmed]
  34. MDR1 gene expression and treatment outcome in acute myeloid leukemia. Pirker, R., Wallner, J., Geissler, K., Linkesch, W., Haas, O.A., Bettelheim, P., Hopfner, M., Scherrer, R., Valent, P., Havelec, L. J. Natl. Cancer Inst. (1991) [Pubmed]
  35. Panhandle PCR strategy to amplify MLL genomic breakpoints in treatment-related leukemias. Megonigal, M.D., Rappaport, E.F., Jones, D.H., Kim, C.S., Nowell, P.C., Lange, B.J., Felix, C.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  36. Specific induction of erythroleukemia and myelogenous leukemia in Sprague-Dawley rats. Huggins, C.B., Grand, L., Ueda, N. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  37. Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Sievers, E.L., Appelbaum, F.R., Spielberger, R.T., Forman, S.J., Flowers, D., Smith, F.O., Shannon-Dorcy, K., Berger, M.S., Bernstein, I.D. Blood (1999) [Pubmed]
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