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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Use of homocysteic acid for selecting mutants at the gltS locus of Escherichia coli K12.

L-Homocysteic acid is toxic to Escherichia coli K12. Sensitivity to this compound is higher in cells which can utilize glutamate as sole carbon source via the Na+-dependent glutamate transport system. Such cells become resistant by mutation at the gltS locus. Sensitivity of both wild-type and glutamate-utilizing strains is greater if cells are growing on acetate as compared with glucose as major carbon source.[1]


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