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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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H-2-linked resistance to mastocytoma in male mice: immune response to a histocompatibility antigen on the X chromosome.

Male hybrids from a cross between female mice of strain C57BL/6Kh and males of strain DBA/2J lived longer after injection of P815 mastocytoma cells of DBA/2 origin than did their female siblings. Responses to the histocompatibility antigen on the X chromosome of the DBA/2 strain may be involved in resistance to the tumor. When the female parent was replaced with a C57BL/6Kh carrying one of several mutations in the H-2 region, this sex effect disappeared in some of the hybrid combinations. Thus, the H-2 complex appears to be involved in the regulation of the immune response to the X-linked histocompatibility antigen in this tumor model.[1]

References

  1. H-2-linked resistance to mastocytoma in male mice: immune response to a histocompatibility antigen on the X chromosome. Kwak, L.W., Kucuk, O., Melvold, R.W., Williams, R.M. Science (1983) [Pubmed]
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