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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Immunoglobulin heavy chain binding protein.

Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy ( IgH) chain in the absence of light (L) chain. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain. Here we show that the protein (which we term immunoglobulin heavy-chain binding protein, BiP) binds non-covalently to free IgH, but not to IgH associated with IgL.[1]

References

  1. Immunoglobulin heavy chain binding protein. Haas, I.G., Wabl, M. Nature (1983) [Pubmed]
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