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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests.

The mutagenicity of diphenylhydantoin (DPH) and its major metabolite, 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), has been re-evaluated by the Ames test using Salmonella typhimurium and, for DPH only, by an in vitro cytogenetic test with human lymphocytes and a turbidimetric assay of tubulin polymerization. As negative results were obtained in all test systems used here, one has to conclude that DPH is devoid of mutagenic properties.[1]

References

  1. Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests. Léonard, A., de Meester, C., Fabry, L., de Saint-Georges, L., Dumont, P. Mutat. Res. (1984) [Pubmed]
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