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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Metabolism of nitropolycyclic aromatic hydrocarbons by human intestinal microflora.

Anaerobic bacterial suspensions from human and rat feces and intestinal contents, and pure cultures of anaerobic bacteria metabolized 1-nitropyrene and 6-nitrobenzo[a]pyrene to 1-aminopyrene and 6-aminobenzo[a]pyrene, respectively. The metabolites were isolated by reversed-phase high performance liquid chromatography and identified by comparison of their chromatographic and mass spectral properties with those of authentic compounds. The results suggest that anaerobic intestinal bacteria could play a significant role in the metabolism of potentially carcinogenic nitropolycyclic aromatic hydrocarbons.[1]

References

  1. Metabolism of nitropolycyclic aromatic hydrocarbons by human intestinal microflora. Cerniglia, C.E., Howard, P.C., Fu, P.P., Franklin, W. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
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