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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Metabolism of nitropolycyclic aromatic hydrocarbons by human intestinal microflora.

Anaerobic bacterial suspensions from human and rat feces and intestinal contents, and pure cultures of anaerobic bacteria metabolized 1-nitropyrene and 6-nitrobenzo[a]pyrene to 1-aminopyrene and 6-aminobenzo[a]pyrene, respectively. The metabolites were isolated by reversed-phase high performance liquid chromatography and identified by comparison of their chromatographic and mass spectral properties with those of authentic compounds. The results suggest that anaerobic intestinal bacteria could play a significant role in the metabolism of potentially carcinogenic nitropolycyclic aromatic hydrocarbons.[1]


  1. Metabolism of nitropolycyclic aromatic hydrocarbons by human intestinal microflora. Cerniglia, C.E., Howard, P.C., Fu, P.P., Franklin, W. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
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