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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Thiram-induced toxic liver injury in male Sprague-Dawley rats.

A single i.p. dose (120 mg/kg) of thiram given to male Sprague-Dawley rats caused a significant increase in the activity of SGOT and SGPT 24 hr post-treatment indicating liver damage. A considerable diminution in the serum cholinesterase activity was also noted in the treated rats as against the control animals. Additional evidence for thiram-induced liver toxicity is provided by the observation that there was approximately 50% inhibition of the activity of hepatic microsomal benzphetamine N-demethylase with a concomitant decrease in the concentration of cytochrome P-450, an important component of the mixed-function oxidase system. Although not significant, hepatic glutathione levels were also depleted by thiram, probably making the liver susceptible to toxic injury.[1]

References

  1. Thiram-induced toxic liver injury in male Sprague-Dawley rats. Dalvi, R.R., Robbins, T.J., Williams, M.K., Deoras, D.P., Donastorg, F., Banks, C. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. (1984) [Pubmed]
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