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Chemical Compound Review

Nobecutan     1- (dimethylthiocarbamoyldisulfan yl)-N,N...

Synonyms: Fernacol, Thiotox, Thiuram, thiram, TMTD, ...
 
 
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Disease relevance of Nobecutan

  • Psychosocial interviews with 2320 male survivors of acute myocardial infarction, participants in the beta-Blocker Heart Attack Trial, permitted the definition of two variables strongly associated with an increased three-year mortality risk [1].
  • Diuretics vs alpha-blockers for treatment of hypertension: lessons from ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [2].
  • In a prospective study of 3,017 patients with transient ischemic attack or minor ischemic stroke from the Dutch Transient Ischemic Attack Trial, the presence or absence of diffuse hypodensity of the white matter on a baseline computed tomography (CT) scan of the brain was related to the occurrence of subsequent stroke [3].
  • Fasting Glucose Levels and Incident Diabetes Mellitus in Older Nondiabetic Adults Randomized to Receive 3 Different Classes of Antihypertensive Treatment: A Report From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) [4].
  • Henoch-Schönlein purpura following thiram exposure [5].
 

Psychiatry related information on Nobecutan

  • The physician's role in minimizing prehospital delay in patients at high risk for acute myocardial infarction: recommendations from the National Heart Attack Alert Program. Working Group on Educational Strategies To Prevent Prehospital Delay in Patients at High Risk for Acute Myocardial Infarction [6].
  • METHOD: We conducted a secondary analysis of survey data from the community-based Panic Attack Care-Seeking Threshold Study. The presence of panic attacks was confirmed in 97 randomly selected adults from randomly selected households screened using the Structured Clinical Interview of DSM-III-R (SCID) [7].
  • Patient and therapist rating scales included Sheehan's Panic and Anxiety Attack Scales, the Marks-Sheehan Phobia Scale, the Hamilton Anxiety Scale, the Hamilton Depression Scale, and the Side Effects Checklist [8].
  • Several fungicides including the dialkyldithiocarbamates as the disulfide (thiram and the related alcohol-abuse drug disulfiram) and metal salts (ziram) also yield S-methyl thiocarbamate metabolites [9].
  • To develop a noninvasive method for psychophysiological assessment of posttraumatic stress disorder (PTSD), 34 victims of the Tokyo Subway Sarin Attack in 1995 including 8 diagnosed as PTSD and 12 controls were examined by a multichannel near-infrared spectroscopy (NIRS) system [10].
 

High impact information on Nobecutan

  • Recommendations for the establishment of primary stroke centers. Brain Attack Coalition [11].
  • An alpha1-adrenergic receptor (alpha1-AR) antagonist increased heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), but it is unknown whether this adverse result was due to alpha1-AR inhibition or a nonspecific drug effect [12].
  • The relation of treatment adherence to mortality after a myocardial infarction was investigated among 2175 participants in the Beta Blocker Heart Attack Trial, which had data for measures of treatment adherence, clinical severity, and the psychological and social features that may influence post-infarction mortality [13].
  • We conducted a case-control analysis to determine the contribution made to mortality by intermittent ST depression (STD) among patients enrolled in the already completed Beta Blocker Heart Attack Trial. METHODS AND RESULTS [14].
  • Propranolol therapy in patients with acute myocardial infarction: the Beta-Blocker Heart Attack Trial [15].
 

Chemical compound and disease context of Nobecutan

 

Biological context of Nobecutan

  • The prevalence of reduced glomerular filtration rate in older hypertensive patients and its association with cardiovascular disease: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [21].
  • From 12 August through 2 September 1993, three influenza outbreaks in Louisiana were investigated using medical-record review, interviews, viral cultures, serology, and active surveillance for influenza-like illness in Louisiana. Attack rates in the outbreaks were 61% (69/114), 42% (24/57), and 45% (23/51) [22].
  • Our results demonstrate that a thiram-induced, 24-h delay in ovulation alters the fertilizability of the released oocyte [23].
  • Effects of Conformation on the Stereochemistry of Solvent Attack on Benzylic beta-Hydroxycarbocations: Mechanisms of Epoxide Hydrolysis Reactions [24].
  • We hypothesized that the reduced litter size in thiram-delayed rats was a consequence of altered oocyte function arising from intrafollicular oocyte aging [23].
 

Anatomical context of Nobecutan

 

Associations of Nobecutan with other chemical compounds

  • Prion Proteins with Insertion Mutations Have Altered N-terminal Conformation and Increased Ligand Binding Activity and Are More Susceptible to Oxidative Attack [30].
  • Awaiting results from interventional studies, this may suggest a need to perform ambulatory monitoring in patients given alpha-blocking agents (or at least supine and standing measurements), and may partially clarify the inferiority of doxazosin in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) [31].
  • METHOD: Data were analyzed from a randomized, double-blind, placebo-controlled 24-week trial (Sertraline Antidepressant Heart Attack Randomized Trial) of sertraline treatment for major depressive disorder in patients hospitalized for ACS [32].
  • Previously, we have shown that a single i.p. injection of 50 mg/kg of thiram, a dithiocarbamate fungicide that decreases norepinephrine synthesis, on proestrus (1300 h) suppresses the LH surge and delays ovulation for 24 h without altering the number of oocytes released [23].
  • Possible pathways for the handling of thiram and dimethyldithiocarbamic acid by yeast are considered with respect to the physiological status, the GSH content, and the activity of glutathione reductase of the cells [33].
 

Gene context of Nobecutan

 

Analytical, diagnostic and therapeutic context of Nobecutan

References

  1. Psychosocial influences on mortality after myocardial infarction. Ruberman, W., Weinblatt, E., Goldberg, J.D., Chaudhary, B.S. N. Engl. J. Med. (1984) [Pubmed]
  2. Diuretics vs alpha-blockers for treatment of hypertension: lessons from ALLHAT. Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Lasagna, L. JAMA (2000) [Pubmed]
  3. Hypodensity of the cerebral white matter in patients with transient ischemic attack or minor stroke: influence on the rate of subsequent stroke. Dutch TIA Trial Study Group. van Swieten, J.C., Kappelle, L.J., Algra, A., van Latum, J.C., Koudstaal, P.J., van Gijn, J. Ann. Neurol. (1992) [Pubmed]
  4. Fasting Glucose Levels and Incident Diabetes Mellitus in Older Nondiabetic Adults Randomized to Receive 3 Different Classes of Antihypertensive Treatment: A Report From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Barzilay, J.I., Davis, B.R., Cutler, J.A., Pressel, S.L., Whelton, P.K., Basile, J., Margolis, K.L., Ong, S.T., Sadler, L.S., Summerson, J. Arch. Intern. Med. (2006) [Pubmed]
  5. Henoch-Schönlein purpura following thiram exposure. Duell, P.B., Morton, W.E. Arch. Intern. Med. (1987) [Pubmed]
  6. The physician's role in minimizing prehospital delay in patients at high risk for acute myocardial infarction: recommendations from the National Heart Attack Alert Program. Working Group on Educational Strategies To Prevent Prehospital Delay in Patients at High Risk for Acute Myocardial Infarction. Dracup, K., Alonzo, A.A., Atkins, J.M., Bennett, N.M., Braslow, A., Clark, L.T., Eisenberg, M., Ferdinand, K.C., Frye, R., Green, L., Hill, M.N., Kennedy, J.W., Kline-Rogers, E., Moser, D.K., Ornato, J.P., Pitt, B., Scott, J.D., Selker, H.P., Silva, S.J., Thies, W., Weaver, W.D., Wenger, N.K., White, S.K. Ann. Intern. Med. (1997) [Pubmed]
  7. Predictors of the development of phobic avoidance. Katerndahl, D.A. The Journal of clinical psychiatry. (2000) [Pubmed]
  8. Alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. Munjack, D.J., Crocker, B., Cabe, D., Brown, R., Usigli, R., Zulueta, A., McManus, M., McDowell, D., Palmer, R., Leonard, M. Journal of clinical psychopharmacology. (1989) [Pubmed]
  9. S-methylation as a bioactivation mechanism for mono- and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors. Staub, R.E., Sparks, S.E., Quistad, G.B., Casida, J.E. Chem. Res. Toxicol. (1995) [Pubmed]
  10. Activation of the prefrontal cortex to trauma-related stimuli measured by near-infrared spectroscopy in posttraumatic stress disorder due to terrorism. Matsuo, K., Kato, T., Taneichi, K., Matsumoto, A., Ohtani, T., Hamamoto, T., Yamasue, H., Sakano, Y., Sasaki, T., Sadamatsu, M., Iwanami, A., Asukai, N., Kato, N. Psychophysiology. (2003) [Pubmed]
  11. Recommendations for the establishment of primary stroke centers. Brain Attack Coalition. Alberts, M.J., Hademenos, G., Latchaw, R.E., Jagoda, A., Marler, J.R., Mayberg, M.R., Starke, R.D., Todd, H.W., Viste, K.M., Girgus, M., Shephard, T., Emr, M., Shwayder, P., Walker, M.D. JAMA (2000) [Pubmed]
  12. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. O'Connell, T.D., Swigart, P.M., Rodrigo, M.C., Ishizaka, S., Joho, S., Turnbull, L., Tecott, L.H., Baker, A.J., Foster, E., Grossman, W., Simpson, P.C. J. Clin. Invest. (2006) [Pubmed]
  13. Treatment adherence and risk of death after a myocardial infarction. Horwitz, R.I., Viscoli, C.M., Berkman, L., Donaldson, R.M., Horwitz, S.M., Murray, C.J., Ransohoff, D.F., Sindelar, J. Lancet (1990) [Pubmed]
  14. Intermittent ST depression and mortality after myocardial infarction. Ruberman, W., Crow, R., Rosenberg, C.R., Rautaharju, P.M., Shore, R.E., Pasternack, B.S. Circulation (1992) [Pubmed]
  15. Propranolol therapy in patients with acute myocardial infarction: the Beta-Blocker Heart Attack Trial. Goldstein, S. Circulation (1983) [Pubmed]
  16. The relationship of treatment adherence to the risk of death after myocardial infarction in women. Gallagher, E.J., Viscoli, C.M., Horwitz, R.I. JAMA (1993) [Pubmed]
  17. What do subgroup analyses reveal about differential response to beta-blocker therapy? The Beta-Blocker Heart Attack Trial experience. Furberg, C.D., Byington, R.P. Circulation (1983) [Pubmed]
  18. Diuretic agents versus beta-blockers. Comparison of effects on mortality, stroke, and coronary events. Furberg, C.D., Cutler, J.A. Hypertension (1989) [Pubmed]
  19. Condom-related allergic contact dermatitis. Harmon, C.B., Connolly, S.M., Larson, T.R. J. Urol. (1995) [Pubmed]
  20. Naratriptan efficacy in migraineurs who respond poorly to oral sumatriptan. Stark, S., Spierings, E.L., McNeal, S., Putnam, G.P., Bolden-Watson, C.P., O'Quinn, S. Headache. (2000) [Pubmed]
  21. The prevalence of reduced glomerular filtration rate in older hypertensive patients and its association with cardiovascular disease: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Rahman, M., Brown, C.D., Coresh, J., Davis, B.R., Eckfeldt, J.H., Kopyt, N., Levey, A.S., Nwachuku, C., Pressel, S., Reisin, E., Walworth, C. Arch. Intern. Med. (2004) [Pubmed]
  22. Three summertime outbreaks of influenza type A. Kohn, M.A., Farley, T.A., Sundin, D., Tapia, R., McFarland, L.M., Arden, N.H. J. Infect. Dis. (1995) [Pubmed]
  23. Abnormal fertilization is responsible for reduced fecundity following thiram-induced ovulatory delay in the rat. Stoker, T.E., Jeffay, S.C., Zucker, R.M., Cooper, R.L., Perreault, S.D. Biol. Reprod. (2003) [Pubmed]
  24. Effects of Conformation on the Stereochemistry of Solvent Attack on Benzylic beta-Hydroxycarbocations: Mechanisms of Epoxide Hydrolysis Reactions. Doan, L., Whalen, D.L. J. Org. Chem. (2006) [Pubmed]
  25. Thiram inhibits angiogenesis and slows the development of experimental tumours in mice. Marikovsky, M. Br. J. Cancer (2002) [Pubmed]
  26. Attack priming in female Syrian golden hamsters is associated with a c-fos-coupled process within the corticomedial amygdala. Potegal, M., Ferris, C.F., Hebert, M., Meyerhoff, J., Skaredoff, L. Neuroscience (1996) [Pubmed]
  27. Genotoxic effects of thiram evaluated by sister-chromatid exchanges in human lymphocytes. Pienkowska, M., Zielenska, M. Mutat. Res. (1990) [Pubmed]
  28. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Teraoka, H., Urakawa, S., Nanba, S., Nagai, Y., Dong, W., Imagawa, T., Tanguay, R.L., Svoboda, K., Handley-Goldstone, H.M., Stegeman, J.J., Hiraga, T. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  29. Parathyroid receptor gene expression by epiphyseal growth plates in rickets and tibial dyschondroplasia. Ben-Bassat, S., Genina, O., Lavelin, I., Leach, R.M., Pines, M. Mol. Cell. Endocrinol. (1999) [Pubmed]
  30. Prion Proteins with Insertion Mutations Have Altered N-terminal Conformation and Increased Ligand Binding Activity and Are More Susceptible to Oxidative Attack. Yin, S., Yu, S., Li, C., Wong, P., Chang, B., Xiao, F., Kang, S.C., Yan, H., Xiao, G., Grassi, J., Tien, P., Sy, M.S. J. Biol. Chem. (2006) [Pubmed]
  31. How should patients treated with alpha-blockers be followed? Insights from an ambulatory blood pressure monitoring database. Ben-Dov, I.Z., Ben-Arie, L., Mekler, J., Bursztyn, M. J. Hypertens. (2006) [Pubmed]
  32. Pharmacoeconomic analysis of sertraline treatment of depression in patients with unstable angina or a recent myocardial infarction. O'Connor, C.M., Glassman, A.H., Harrison, D.J. The Journal of clinical psychiatry. (2005) [Pubmed]
  33. Thiram and dimethyldithiocarbamic acid interconversion in Saccharomyces cerevisiae: a possible metabolic pathway under the control of the glutathione redox cycle. Elskens, M.T., Penninckx, M.J. Appl. Environ. Microbiol. (1997) [Pubmed]
  34. Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates. Atanasov, A.G., Tam, S., Röcken, J.M., Baker, M.E., Odermatt, A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  35. Reduction of glucocorticoid receptor ligand binding by the 11-beta hydroxysteroid dehydrogenase type 2 inhibitor, Thiram. Garbrecht, M.R., Krozowski, Z.S., Snyder, J.M., Schmidt, T.J. Steroids (2006) [Pubmed]
  36. Peripheral Blood CD161(+) T Cells from Asthmatic Patients are Activated During Asthma Attack and Predominantly Produce IFN-gamma. González-Hernández, Y., Pedraza-Sánchez, S., Blandón-Vijil, V., Del Río-Navarro, B.E., Vaughan, G., Moreno-Lafont, M., Escobar-Gutiérrez, A. Scand. J. Immunol. (2007) [Pubmed]
  37. Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia. Rath, N.C., Richards, M.P., Huff, W.E., Huff, G.R., Balog, J.M. J. Comp. Pathol. (2005) [Pubmed]
  38. Splenectomy done during hematologic remission to prevent relapse in patients with thrombotic thrombocytopenic purpura. Crowther, M.A., Heddle, N., Hayward, C.P., Warkentin, T., Kelton, J.G. Ann. Intern. Med. (1996) [Pubmed]
  39. Perspectives from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial--Lipid Lowering Trial and the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm. Brown, W.V., Moussa, M. Curr. Opin. Lipidol. (2003) [Pubmed]
  40. Identifying the risk of death following hospital discharge in patients admitted with a suspected acute myocardial infarction in whom the diagnosis is not confirmed. Packham, C., Gray, D., Silcocks, P., Hampton, J. Eur. Heart J. (2000) [Pubmed]
  41. Diuretic agents and beta-blockers in the treatment of hypertension. Dollery, C. Hypertension (1989) [Pubmed]
 
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