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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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ATP and other purine nucleotides stimulate the inactivation of ornithine transcarbamylase by broken lysosomes.

Ornithine transcarbamylase ( OTC) is very stable in rat liver homogenates, or mitochondria. However, pure OTC from rat or beef liver is inactivated by broken lysosomes. ATP and a number of purine nucleotides, particularly epsilon-ATP, stimulate the inactivation of OTC by broken lysosomes. Inactivation of OTC by trypsin and elastase is also stimulated by epsilon-ATP. Carbamoyl phosphate protects OTC against proteolytic attack by elastase or by broken lysosomes. Thus, environmental factors, e.g., ATP and carbamoyl phosphate, appear to influence OTC stability to proteases.[1]

References

  1. ATP and other purine nucleotides stimulate the inactivation of ornithine transcarbamylase by broken lysosomes. Navarro, A., Grisolía, S. FEBS Lett. (1984) [Pubmed]
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