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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines.

Stimulus generalization studies were conducted using rats trained to discriminate 1.0 mg/kg of the phenalkylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane ( DOM) from saline in a two-lever operant procedure. The results suggest that certain indolealkylamine hallucinogens, including LSD and several alpha-methyltryptamine, N,N-dialkyltryptamine and beta-carboline derivatives, are capable of producing stimulus effects similar to those produced by DOM. Furthermore, for twelve agents where human data are available, a significant correlation exists between discrimination-derived ED50 values and hallucinogenic potency.[1]


  1. DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines. Glennon, R.A., Young, R., Jacyno, J.M., Slusher, M., Rosecrans, J.A. Eur. J. Pharmacol. (1983) [Pubmed]
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