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Chemical Compound Review

Indopan     1-(1H-indol-3-yl)propan-2- amine

Synonyms: CHEMBL30713, zlchem 1088, SureCN274268, Bio-0640, AG-E-97799, ...
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High impact information on alpha-Methyltryptamine

  • Racemic alpha-methyltryptamine and Nomega-methyltryptamine were also shown to be substrates for AANAT, again with reduced kcat and kcat/Km compared with serotonin [1].
  • Taking advantage of a proposed hydrophobic region on 5-HT2 receptors previously identified by radioligand-binding studies utilizing various phenylisopropylamine derivatives, we prepared and evaluated several N1 - and/or C7-alkyl-substituted derivatives of alpha-methyltryptamine in order to improve its affinity and selectivity [2].
  • Ipsilateral electrocortical arousal only, resulted from infusion of alpha-methyltryptamine into the hypothalamus or mesencephalon of fowl encephale isole preparations [3].
  • 2 Tryptamine and alpha-methyltryptamine, given intraventricularly or into the hypothalamus of intact fowls evoked behavioural and bilateral electrocortical arousal, postural changes, elevation of body temperature and tachypnoea; behavioural and bilateral electrocortical arousal were obtained with infusions into the mesencephalon [3].
  • The results suggest that certain indolealkylamine hallucinogens, including LSD and several alpha-methyltryptamine, N,N-dialkyltryptamine and beta-carboline derivatives, are capable of producing stimulus effects similar to those produced by DOM [4].

Associations of alpha-Methyltryptamine with other chemical compounds


  1. Indoleamine analogs as probes of the substrate selectivity and catalytic mechanism of serotonin N-acetyltransferase. Khalil, E.M., De Angelis, J., Cole, P.A. J. Biol. Chem. (1998) [Pubmed]
  2. Binding of indolylalkylamines at 5-HT2 serotonin receptors: examination of a hydrophobic binding region. Glennon, R.A., Chaurasia, C., Titeler, M. J. Med. Chem. (1990) [Pubmed]
  3. Tryptamines and some other substances affecting waking and sleep in fowls. Marley, E., Nistiò, G. Br. J. Pharmacol. (1975) [Pubmed]
  4. DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines. Glennon, R.A., Young, R., Jacyno, J.M., Slusher, M., Rosecrans, J.A. Eur. J. Pharmacol. (1983) [Pubmed]
  5. Sensitive determination of alpha-methyltryptamine (AMT) and 5-methoxy-N,N-diisopropyltryptamine (5MeO-DIPT) in whole blood and urine using gas chromatography-mass spectrometry. Ishida, T., Kudo, K., Kiyoshima, A., Inoue, H., Tsuji, A., Ikeda, N. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2005) [Pubmed]
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