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Chemical Compound Review

DMAc     N,N-dimethylethanamide

Synonyms: Hallucinogen, HSDB 74, CHEMBL11873, NSC-3138, CCRIS 4623, ...
 
 
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Disease relevance of Dimethyl acetamide

 

Psychiatry related information on Dimethyl acetamide

  • In general, the evidence suggests that the prevalence of substance abuse in schizophrenia is comparable to that in the general population, with the possible exceptions of stimulant and hallucinogen abuse, which may be greater in patients with schizophrenia [6].
  • CONCLUSIONS: While the prevailing view was that the activation of 5-HT(2) receptors is solely responsible for hallucinogenic drug effects, these results support a role for 5-HT(1A) receptors in the effects of the indoleamine hallucinogen 5-MeO-DMT on locomotor activity and PPI in rats [7].
  • Among them, 83 had a diagnosis of alcohol dependence, 41 of heroin dependence and the remaining 17 cases of sedative, glue or hallucinogen dependence [8].
  • Psychometric assessment of the Hallucinogen Rating Scale [9].
  • Two variables were predictive of sexual risk-taking: higher level of hallucinogen use and sexual relationship with an IDU [10].
 

High impact information on Dimethyl acetamide

 

Chemical compound and disease context of Dimethyl acetamide

 

Biological context of Dimethyl acetamide

 

Anatomical context of Dimethyl acetamide

  • Number of surviving spermatozoa diminished progressively with increasing DMA concentrations in all species [26].
  • A major role for thalamocortical afferents in serotonergic hallucinogen receptor function in the rat neocortex [27].
  • CONCLUSION: It is discussed that ayahuasca-induced survival of binocular rivalry at high DSA rates may be related to slow visual processing and increased mean dominance periods may result from hallucinogen-induced alteration of gamma oscillations in the visual pathways [28].
  • Consistent with a partial agonist action, LSD and DOI blocked the 5-HT excitation of piriform cortical interneurons only at the higher hallucinogen concentrations tested [29].
  • The effects of the hallucinogen, harmaline (HME), and its congeners on human red blood cell (RBC) transport were studied [30].
 

Associations of Dimethyl acetamide with other chemical compounds

 

Gene context of Dimethyl acetamide

  • For example, 7b substituted for LSD in the drug discrimination assay with an ED50 of 61 nmol/kg and had Kj values in the nanomolar to subnanomolar range for the displacement of radioligand from rat and human 5-HT2 receptors, making it one of the most potent hallucinogen-like phenylalkylamine derivatives reported to date [36].
  • 5-MeO-DIPT is thus effective in two rodent models of 5-HT2 agonist activity, and has affinity at receptors relevant to hallucinogen effects [37].
  • In the present work, the effect of DMF and of the structurally related N,N-dimethylacetamide (DMAc) on the activating enzyme and the nature of the reactive species involved in the mechanism of P450 inactivation by the two chemicals were investigated in vitro [38].
  • The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptors [39].
  • Evidence for a common biological basis of the Absorption trait, hallucinogen effects, and positive symptoms: epistasis between 5-HT2a and COMT polymorphisms [40].
 

Analytical, diagnostic and therapeutic context of Dimethyl acetamide

References

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