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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The in vitro effects of D-penicillamine upon anti-AChR production by thymic and peripheral blood lymphocytes from patients with myasthenia gravis.

D-Penicillamine added to lymphocyte cultures from myasthenia gravis patients infrequently and inconsistently stimulated anti-AChR production. This usually occurred in the presence of pokeweed mitogen (PWM), and often only at a single concentration of D-penicillamine which varied among patients. The change was typically paralleled by an increase in total IgG production of similar magnitude, suggesting that the effect was nonspecific. D-penicillamine did not affect AChR expression in cultured thymic adherent cells. These data provide no evidence that penicillamine induces myasthenia gravis by direct stimulation of anti-AChR antibody-producing cells.[1]

References

  1. The in vitro effects of D-penicillamine upon anti-AChR production by thymic and peripheral blood lymphocytes from patients with myasthenia gravis. Scadding, G.K., Calder, L., Newsom-Davis, J. Muscle Nerve (1983) [Pubmed]
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