The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Phytolacca americana

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Phytolacca americana


High impact information on Phytolacca americana

  • We report here that human thyroid follicular cells which are normally negative for HLA-DR molecules, can be induced to express these antigens when cultured with phytohaemagglutinin (PHA), concanavalin A (Con A) or pokeweed mitogen (PWM) [6].
  • We describe here a culture system in which production of erythropoietic progenitor cells can be maintained for over 6 months in the absence of an adherent stromal layer and in the absence of added Epo, but in the presence of pokeweed mitogen-stimulated spleen cell conditioned medium (PWSCM) [7].
  • A pan-B immunotoxin was synthesized by linking B43, a human B cell-specific mAb, to pokeweed antiviral protein (PAP) [8].
  • T cells (Trac) co-cultured with normal allogeneic non-T cells and pokeweed mitogen resulted in only IgG and IgA PFC, with little or no IgM secretion [9].
  • Incubation of CId-1B hybrid cells with concanavalin A or lentil lectin resulted in capping of the CId-1 determinant, whereas incubation with pokeweed mitogen, lipopolysaccharide, phytohemagglutinin, and wheat germ agglutinin had no effect on the cell surface distribution of the CId-1 molecule [10].

Chemical compound and disease context of Phytolacca americana


Biological context of Phytolacca americana


Anatomical context of Phytolacca americana


Associations of Phytolacca americana with chemical compounds

  • When PBL from normal, carrier, and CID horses were stimulated by phytohemagglutinin (PHA), concanavalin A, or pokeweed mitogen, [3H]thymidine uptake was inhibited by adenosine (0.1 microM) to 1.0 mM) in a dose-dependent manner [26].
  • Addition of RLB9-7 to autologous peripheral blood mononuclear cells in the presence of urushiol inhibited the pokeweed mitogen-driven IgG synthesis [27].
  • Mitogen activation of lc was associated with decreased viral replication when either T-cell mitogens (concanavalin A, phytohemagglutinin, or pokeweed mitogen) or a B-cell mitogen (dextran sulfate) was used [28].
  • In an attempt to determine a functional role for the sterol in such cells, we studied the effect of 1,25-(OH)2-D3 on DNA synthesis and Ig production by normal human peripheral blood mononuclear (PBM) cells activated in vitro by the polyclonal lymphocyte activators pokeweed mitogen and phytohemagglutinin, and the specific antigen dermatophyton O [29].
  • Pokeweed antiviral protein (PAP) from the summer leaves of Phytolacca americana was purified and conjugated via N-succinimidyl-3-(2-pyridyldithio)propionate to 9.2.27 anti-melanoma antibody to a glycoprotein-proteoglycan complex [30].

Gene context of Phytolacca americana

  • In undepleted IBD cultures, TNF-alpha, IL-1alpha and beta, and IL-10 were markedly up-regulated by pokeweed mitogen stimulation; IL-1alpha and beta and IL-10 were also up-regulated by stimulation of interferon gamma and lipopolysaccharide in combination [31].
  • We have previously reported the detection of granulocyte-macrophage-CSF (GM-CSF) in murine stromal cultures and its induction by the lectin Pokeweed mitogen [32].
  • EBI3 expression in vitro is induced in EBV-negative cell lines by expression of the EBV latent infection membrane protein-1 and in peripheral blood mononuclear cells by pokeweed mitogen stimulation [33].
  • When used in combination with plateau concentrations of pokeweed mitogen mouse spleen cell conditioned medium or granulocyte-macrophage colony stimulating factor (CSF), MGF enhanced in greater than additive fashion colony formation by CFU-GM [34].
  • In the controls, IL-4 inhibited Ig production in response to Staphylococcus aureus and pokeweed mitogen stimulation [35].

Analytical, diagnostic and therapeutic context of Phytolacca americana


  1. Production of predominantly polymeric IgA by human peripheral blood lymphocytes stimulated in vitro with mitogens. Kutteh, W.H., Koopman, W.J., Conley, M.E., Egan, M.L., Mestecky, J. J. Exp. Med. (1980) [Pubmed]
  2. Suppressor and cytolytic cell function in multiple sclerosis. Effects of cyclosporine A and interleukin 2. Bania, M.B., Antel, J.P., Reder, A.T., Nicholas, M.K., Arnason, B.G. J. Clin. Invest. (1986) [Pubmed]
  3. Inhibition of N-linked oligosaccharide trimming mannosidases blocks human B cell development. Tulp, A., Barnhoorn, M., Bause, E., Ploegh, H. EMBO J. (1986) [Pubmed]
  4. Human transferrin receptor: expression of the receptor is assigned to chromosome 3. Enns, C.A., Suomalainen, H.A., Gebhardt, J.E., Schröder, J., Sussman, H.H. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  5. In vitro hemopoiesis of marrow cells from myelodysplastic patients: effects of mitogen-stimulated spleen cell-conditioned medium and vitamin A and D derivatives. Fabian, I., Riklis, I., Tatarsky, I., Nagler, A. Cancer Res. (1986) [Pubmed]
  6. Lectin-induced expression of DR antigen on human cultured follicular thyroid cells. Pujo-Borrell, R., Hanafusa, T., Chiovato, L., Bottazzo, G.F. Nature (1983) [Pubmed]
  7. Long-term culture of murine erythropoietic progenitor cells in the absence of an adherent layer. Wendling, F., Shreeve, M.M., McLeod, D.L., Axelrad, A.A. Nature (1983) [Pubmed]
  8. Use of a novel colony assay to evaluate the cytotoxicity of an immunotoxin containing pokeweed antiviral protein against blast progenitor cells freshly obtained from patients with common B-lineage acute lymphoblastic leukemia. Uckun, F.M., Gajl-Peczalska, K.J., Kersey, J.H., Houston, L.L., Vallera, D.A. J. Exp. Med. (1986) [Pubmed]
  9. Human malignant T cells capable of inducing an immunoglobulin class switch. Mayer, L., Posnett, D.N., Kunkel, H.G. J. Exp. Med. (1985) [Pubmed]
  10. T cell hybrids that express a VH idiotope-related determinant on a glycoprotein distinct from H-2, Thy-1, and Lyt-1 molecules. Chanh, T.C., Cooper, M.D. J. Exp. Med. (1983) [Pubmed]
  11. Differential effects of propranolol on lymphocyte rosette formation and response to plant mitogens. Dunne, J.V., Peters, C.J., Moore, T.L., Vaughan, J.H. Arthritis Rheum. (1978) [Pubmed]
  12. Severe allergic reactions to foods are predicted by increases of CD4+CD45RO+ T cells and loss of L-selectin expression. Beyer, K., Niggemann, B., Nasert, S., Renz, H., Wahn, U. J. Allergy Clin. Immunol. (1997) [Pubmed]
  13. Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation. Saito, K., Nowak, T.S., Suyama, K., Quearry, B.J., Saito, M., Crowley, J.S., Markey, S.P., Heyes, M.P. J. Neurochem. (1993) [Pubmed]
  14. The influence of ethionine-supplemented soy protein diet on cell-mediated and humoral immunity. Radix, P.M., Walters, C.S., Adkins, J.A. J. Nutr. (1983) [Pubmed]
  15. Blood lymphocyte proliferation, cytokine secretion and appearance of T cells with activation surface markers in cultures with Helicobacter pylori. Comparison of the responses of subjects with and without antibodies to H. pylori. Karttunen, R. Clin. Exp. Immunol. (1991) [Pubmed]
  16. The B cell surface molecule B1 is functionally linked with B cell activation and differentiation. Tedder, T.F., Boyd, A.W., Freedman, A.S., Nadler, L.M., Schlossman, S.F. J. Immunol. (1985) [Pubmed]
  17. Regulation of IgE and IgG4 responses by allergen specific T-cell clones to bee venom phospholipase A2 in vitro. Carballido, J.M., Carballido-Perrig, N., Oberli-Schrämmli, A., Heusser, C.H., Blaser, K. J. Allergy Clin. Immunol. (1994) [Pubmed]
  18. Rabbit leukocyte surface antigens defined by monoclonal antibodies. De Smet, W., Vaeck, M., Smet, E., Brys, L., Hamers, R. Eur. J. Immunol. (1983) [Pubmed]
  19. Differential activation of cytokine genes in normal CD4-bearing T cells is stimulus dependent. Carding, S.R., West, J., Woods, A., Bottomly, K. Eur. J. Immunol. (1989) [Pubmed]
  20. Analysis of murine megakaryocyte colony size and ploidy: effects of interleukin-3. Segal, G.M., Stueve, T., Adamson, J.W. J. Cell. Physiol. (1988) [Pubmed]
  21. Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures. Paavonen, T., Andersson, L.C., Adlercreutz, H. J. Exp. Med. (1981) [Pubmed]
  22. Pathogenesis of of cytomegalovirus infection. I. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction. Olding, L.B., Jensen, F.C., Oldstone, M.B. J. Exp. Med. (1975) [Pubmed]
  23. Reversal of infectious mononucleosis-associated suppressor T cell activity by D-mannose. Tosato, G., Pike, S.E., Blaese, R.M. J. Exp. Med. (1983) [Pubmed]
  24. Human b-cell differentiation. I. Analysis of immunoglobulin heavy chain switching using monoclonal anti-immunoglobulin M, G, and A antibodies and pokeweed mitogen-induced plasma cell differentiation. Kuritani, T., Cooper, M.D. J. Exp. Med. (1982) [Pubmed]
  25. Immunomodulatory effect of procainamide in man. Inhibition of human suppressor T-cell activity in vitro. Ochi, T., Goldings, E.A., Lipsky, P.E., Ziff, M. J. Clin. Invest. (1983) [Pubmed]
  26. In vitro of adenosine on lymphocytes and erythrocytes from horses with combined immunodeficiency. Magnuson, N.S., Perryman, L.E. J. Clin. Invest. (1979) [Pubmed]
  27. Urushiol (poison ivy)-triggered suppressor T cell clone generated from peripheral blood. Kalish, R.S., Morimoto, C. J. Clin. Invest. (1988) [Pubmed]
  28. Determinants of susceptibility and resistance to feline leukemia virus infection. II. Susceptibility of feline lymphocytes to productive feline leukemia virus infection. Rojko, J.L., Hoover, E.A., Finn, B.L., Olsen, R.G. J. Natl. Cancer Inst. (1981) [Pubmed]
  29. 1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. Lemire, J.M., Adams, J.S., Sakai, R., Jordan, S.C. J. Clin. Invest. (1984) [Pubmed]
  30. Immunotoxins to a human melanoma-associated antigen: resistance to pokeweed antiviral protein conjugates in vitro. Morgan, A.C., Bordonaro, J., Pearson, J.W., Sivam, G. J. Natl. Cancer Inst. (1987) [Pubmed]
  31. Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease. Rugtveit, J., Nilsen, E.M., Bakka, A., Carlsen, H., Brandtzaeg, P., Scott, H. Gastroenterology (1997) [Pubmed]
  32. Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma. Kittler, E.L., McGrath, H., Temeles, D., Crittenden, R.B., Kister, V.K., Quesenberry, P.J. Blood (1992) [Pubmed]
  33. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. Devergne, O., Hummel, M., Koeppen, H., Le Beau, M.M., Nathanson, E.C., Kieff, E., Birkenbach, M. J. Virol. (1996) [Pubmed]
  34. Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells. Broxmeyer, H.E., Hangoc, G., Cooper, S., Anderson, D., Cosman, D., Lyman, S.D., Williams, D.E. Exp. Hematol. (1991) [Pubmed]
  35. Interleukin 4 inhibits polyclonal immunoglobulin secretion and cytokine production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Briolay, J., Dechanet, J., Blanchard, D., Banchereau, J., Miossec, P. J. Clin. Immunol. (1992) [Pubmed]
  36. Autoantibodies against CD4 cells are associated with CD4 helper defects in human immunodeficiency virus-infected patients. Weimer, R., Daniel, V., Zimmermann, R., Schimpf, K., Opelz, G. Blood (1991) [Pubmed]
  37. Seasonal variations in different forms of pokeweed antiviral protein, a potent inactivator of ribosomes. Houston, L.L., Ramakrishnan, S., Hermodson, M.A. J. Biol. Chem. (1983) [Pubmed]
  38. Suppression of pokeweed mitogen-stimulated immunoglobulin production in patients with rheumatoid arthritis after treatment with total lymphoid irradiation. Kotzin, B.L., Strober, S., Kansas, G.S., Terrell, C.P., Engleman, E.G. J. Immunol. (1984) [Pubmed]
  39. Identification and localization of immunoglobulin binding factor in bronchoalveolar lavage fluid from healthy smokers. Ogushi, F., Sone, S., Tani, K., Takehara, H., Endo, T., Haku, T., Nakamura, Y., Ogura, T., Kamada, M., Aono, T. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  40. Thiol-inducing and immunoregulatory effects of flavonoids in peripheral blood mononuclear cells from patients with end-stage diabetic nephropathy. Dietzmann, J., Thiel, U., Ansorge, S., Neumann, K.H., Täger, M. Free Radic. Biol. Med. (2002) [Pubmed]
WikiGenes - Universities