Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Clark, R.L. et al.

Studies of enzyme polymorphism in the Kamuela population of Drosophila mercatorum. III. Effects of variation at the alpha GPD locus and subflight stress on the energy charge and glycolytic intermediate concentrations.

We have employed a "level crossing" strategy to study the primary effects of an enzyme polymorphism in Drosophila mercatorum. This strategy consists of following genetic differences across intervening phenotypes to possible fitness effects. In this paper, we report the steady state concentrations of the glycolytic intermediates and the adenylates (intervening phenotypes) in two genotypes (alpha GPD-F, alpha GPD-S) at two stress levels (rest, subflight). We did not detect a genotype or a genotype by stress interaction effect on glycolytic intermediate or adenylate concentrations despite the ability of the experimental design to detect a 20 to 50% difference from the mean of a control. The flux of glycolysis is adequate to maintain the energy charge in both strains under the stress levels considered. If there is a fitness difference between these alpha GPD variants, it is unlikely to be a result of modifications of glycolysis. Subflight stress, however, resulted in an increase in metabolic flux. The observed pattern of intermediate concentration differences is consistent with the modulation of glycolysis by the ratio of the ATP and AMP concentrations acting on phosphofructokinase activity.[1]

References

Studies of enzyme polymorphism in the Kamuela population of Drosophila mercatorum. III. Effects of variation at the alpha GPD locus and subflight stress on the energy charge and glycolytic intermediate concentrations. Clark, R.L., Boerwinkle, E., Brewer, G.J., Sing, C.F. Genetics (1983) [Pubmed]

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