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Gene Review

Gpdh  -  Glycerol 3 phosphate dehydrogenase

Drosophila melanogaster

Synonyms: CG9042, DROGPDHA, DmG3PDH, Dmel\CG9042, G3PDH, ...
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Disease relevance of Gpdh


High impact information on Gpdh

  • I review the evolution of two genes, Gpdh and Sod [3].
  • The process of transcript terminus formation inside the retrotransposon insertion reduces the level of the Gpdh transcript that contains exon 8 and increases the level of the transcript that contains exons 1-7 [4].
  • Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster [4].
  • To understand the underlying molecular basis of these isoforms, we have sequenced a 5.8-kilobase region of the Drosophila genome that contains the entire Gpdh locus [5].
  • Two other enzyme loci exhibited a correlated variation with Adh-F--i.e., an increase of the S allele of glycerol-3-phosphate dehydrogenase (NAD+) (sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase, EC and of the F allele of glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate:NADP+ 1-oxidoreductase, EC [6].

Biological context of Gpdh


Anatomical context of Gpdh


Associations of Gpdh with chemical compounds


Physical interactions of Gpdh


Other interactions of Gpdh


Analytical, diagnostic and therapeutic context of Gpdh


  1. Isolation of a genomic clone for Drosophila sn-glycerol-3-phosphate dehydrogenase using synthetic oligonucleotides. Cook, J.L., Shaffer, J.B., Bewley, G.C., MacIntyre, R.J., Wright, D.A. J. Biol. Chem. (1986) [Pubmed]
  2. Polymorphism at the Adh and alpha Gpdh loci in Drosophila melanogaster: effects of rearing temperature on developmental rate, body weight, and some biochemical parameters. Oudman, L., Van Delden, W., Kamping, A., Bijlsma, R. Heredity (1991) [Pubmed]
  3. Vagaries of the molecular clock. Ayala, F.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Retrotransposon insertion induces an isozyme of sn-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster. Wilanowski, T.M., Gibson, J.B., Symonds, J.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. Structural characterization of the alpha-glycerol-3-phosphate dehydrogenase-encoding gene of Drosophila melanogaster. von Kalm, L., Weaver, J., DeMarco, J., MacIntyre, R.J., Sullivan, D.T. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  6. Short-range genetic structure of Drosophila melanogaster populations in an Afrotropical urban area and its significance. Vouidibio, J., Capy, P., Defaye, D., Pla, E., Sandrin, J., Csink, A., David, J.R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Selection affecting enzyme polymorphisms in enclosed Drosophila populations maintained in a natural environment. Oakeshott, J.G., Wilson, S.R., Knibb, W.R. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Defective P element insertions affect the expression of sn-glycerol-3-phosphate dehydrogenase alleles in natural populations of Drosophila melanogaster. Reed, D.S., Gibson, J.B. Proc. Biol. Sci. (1993) [Pubmed]
  9. Drosophila sn-glycerol-3-phosphate dehydrogenase isozymes are generated by alternate pathways of RNA processing resulting in different carboxyl-terminal amino acid sequences. Cook, J.L., Bewley, G.C., Shaffer, J.B. J. Biol. Chem. (1988) [Pubmed]
  10. The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria. Miwa, S., Brand, M.D. Biochim. Biophys. Acta (2005) [Pubmed]
  11. Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes. Hunt, C.R., Ro, J.H., Dobson, D.E., Min, H.Y., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  12. RNA directed synthesis of catalytically active Drosophila sn-glycerol-3-phosphate dehydrogenase in Xenopus oocytes. Wright, D.A., Shaffer, J.B., Bewley, G.C. J. Biol. Chem. (1985) [Pubmed]
  13. Developmental regulation of glycerol-3-phosphate dehydrogenase synthesis in Drosophila. Sullivan, D.T., Donovan, F.A., Skuse, G. Biochem. Genet. (1983) [Pubmed]
  14. Flight muscle function in Drosophila requires colocalization of glycolytic enzymes. Wojtas, K., Slepecky, N., von Kalm, L., Sullivan, D. Mol. Biol. Cell (1997) [Pubmed]
  15. Effect of dietary carbohydrates and ethanol on expression of genes encoding sn-glycerol-3-phosphate dehydrogenase, aldolase, and phosphoglycerate kinase in Drosophila larvae. Lissemore, J.L., Baumgardner, C.A., Geer, B.W., Sullivan, D.T. Biochem. Genet. (1990) [Pubmed]
  16. Triglyceride pools, flight and activity variation at the Gpdh locus in Drosophila melanogaster. Merritt, T.J., Sezgin, E., Zhu, C.T., Eanes, W.F. Genetics (2006) [Pubmed]
  17. Superoxide and hydrogen peroxide production by Drosophila mitochondria. Miwa, S., St-Pierre, J., Partridge, L., Brand, M.D. Free Radic. Biol. Med. (2003) [Pubmed]
  18. Conserved (CT)n.(GA)n repeats in the non-coding regions at the Gpdh locus are binding sites for the GAGA factor in drosophila melanogaster and its sibling species. Tchoubrieva, E.B., Gibson, J.B. Genetica (2004) [Pubmed]
  19. The role of gene conversion in determining sequence variation and divergence in the Est-5 gene family in Drosophila pseudoobscura. King, L.M. Genetics (1998) [Pubmed]
  20. Fitness of wild-caught Drosophila melanogaster females: allozyme variants of GPDH, ADH, PGM, and EST. Ochando, M.D., Ayala, F.J. Genetica (1999) [Pubmed]
  21. Structure of variation in enzyme activity in natural Drosophila melanogaster populations. Pecsenye, K., Saura, A. Hereditas (2002) [Pubmed]
  22. Molecular cloning and analysis of the chromosomal region 26A of Drosophila melanogaster. Knipple, D.C., Fuerst, T.R., MacIntyre, R.J. Mol. Gen. Genet. (1991) [Pubmed]
  23. Distribution of polymorphic gene duplication at the Gpdh locus in natural populations of Drosophila melanogaster. Koga, A., Baba, H., Kusakabe, S., Hattori, M., Mukai, T. J. Mol. Evol. (1993) [Pubmed]
  24. Cloning and sequence analysis of Gpdh in Callosobruchus chinensis (Coleoptera: Bruchidae). Park, K.S., Bae, Y.J., Yeau, S.H., Kang, S.J. Mol. Cells (2001) [Pubmed]
  25. Analysis of l-glycerol-3-phosphate dehydrogenase mutants in Drosophila melanogaster: complementation for intracellular degradation of the mutant polypeptide. Bewley, G.C., DeZurik, J.M., Pagelson, G. Mol. Gen. Genet. (1980) [Pubmed]
  26. Analyses of genetic variants of L-glycerol-3-phosphate dehydrogenase in Drosophila melanogaster by two-dimensional gel electrophoresis and immunoelectrophoresis. Lee, C.Y., Niesel, D., Bewley, G.C. Biochem. Genet. (1980) [Pubmed]
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