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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Antigenicity and evolution amongst recent influenza viruses of H1N1 subtype.

The sequence of the HA1 subunit region of the haemagglutinin gene of influenza A/USSR/90/77, and A/Brazil/11/78, A/Lackland/3/78, A/England/333/80 and A/India/6263/80 was determined by dideoxy-sequencing methods using total virion RNA and specific oligonucleotide primers for reverse transcriptase. These 1977-1980 strains share a minimum of 85% amino acid sequence homology with influenza A/PR/8/34. Most of the surface amino acid substitutions which occurred during the evolution of A/PR/8/34 to A/USSR/90/77 and subsequently in the 1978-1980 strains are located in the 4 antigenic sites previously defined by an analysis of laboratory-selected mutants of A/PR/8/34. We deduce an evolutionary pathway for the 1977-80 strains and suggest their different epidemic properties may be a consequence of only a few amino acid changes.[1]


  1. Antigenicity and evolution amongst recent influenza viruses of H1N1 subtype. Raymond, F.L., Caton, A.J., Cox, N.J., Kendal, A.P., Brownlee, G.G. Nucleic Acids Res. (1983) [Pubmed]
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