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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Orthomyxoviridae

  • We present a model for the functions and movements of the influenza virus P proteins (PB1, PB2, and PA) as they transcribe the virion RNAs (vRNAs) into messenger RNAs (mRNAs) [1].
  • (2005) now report remarkable similarities between the polymerase genes of the influenza virus that caused the 1918 Spanish influenza pandemic and those of avian influenza viruses [2].
  • Moreover, animals inoculated with recombinants expressing the influenza virus haemagglutinin (HA), the hepatitis B virus surface antigen, and type 1 herpesvirus glycoprotein D were protected against subsequent challenge with the corresponding virus [3].
  • Experiments with influenza virus antigens have supported the view that class II MHC molecules can present exogenous but not endogenous antigen, whereas the observation that class II MHC molecules present measles virus non-membrane antigens by a chloroquine-insensitive pathway suggests that this is not always the case [4].
  • Here, we demonstrate that mice lacking PKR are predisposed to lethal intranasal infection by the usually innocuous vesicular stomatitis virus, and also display increased susceptibility to influenza virus infection [5].

Psychiatry related information on Orthomyxoviridae


High impact information on Orthomyxoviridae


Chemical compound and disease context of Orthomyxoviridae


Biological context of Orthomyxoviridae


Anatomical context of Orthomyxoviridae


Gene context of Orthomyxoviridae

  • To examine further the role of this cytokine in the control of viral infections, mice with a targeted mutation in the IFN-gamma gene were infected with influenza virus, and the in vivo antibody and cell-mediated immune response to viral infection were examined [29].
  • MNL collected at 1, 4, and 24 h after exposure to influenza virus (which induces net IL-1 bioactivity) showed enhanced expression of ICAM-1 and LFA-1 relative to sham-exposed MNL and exhibited cell clustering [30].
  • The complete nucleotide sequence of the neuraminidase gene of influenza virus B/Lee/40 was derived from a cloned cDNA copy of virion RNA segment 6 and its corresponding mRNA [31].
  • Virus-specific, perforin-dependent CD8(+) CTL were detected in freshly isolated cells from the mouse lung parenchyma but not from the mediastinal lymph nodes (MLN), where they are primed, or from the spleen during primary influenza virus infection [32].
  • The murine influenza virus resistance locus Mx consists of more than one interferon-responsive transcription unit [33].

Analytical, diagnostic and therapeutic context of Orthomyxoviridae


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  2. The genesis of a pandemic influenza virus. Russell, C.J., Webster, R.G. Cell (2005) [Pubmed]
  3. Recombinant vaccinia virus primes and stimulates influenza haemagglutinin-specific cytotoxic T cells. Bennink, J.R., Yewdell, J.W., Smith, G.L., Moller, C., Moss, B. Nature (1984) [Pubmed]
  4. Class II MHC molecules can use the endogenous pathway of antigen presentation. Nuchtern, J.G., Biddison, W.E., Klausner, R.D. Nature (1990) [Pubmed]
  5. Essential role for the dsRNA-dependent protein kinase PKR in innate immunity to viral infection. Balachandran, S., Roberts, P.C., Brown, L.E., Truong, H., Pattnaik, A.K., Archer, D.R., Barber, G.N. Immunity (2000) [Pubmed]
  6. V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin. Clarke, S.H., Staudt, L.M., Kavaler, J., Schwartz, D., Gerhard, W.U., Weigert, M.G. J. Immunol. (1990) [Pubmed]
  7. Detection of toxic viral-associated double-stranded RNA (dsRNA) in influenza-infected lung. Majde, J.A., Brown, R.K., Jones, M.W., Dieffenbach, C.W., Maitra, N., Krueger, J.M., Cady, A.B., Smitka, C.W., Maassab, H.F. Microb. Pathog. (1991) [Pubmed]
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  9. Obstetrical complications and subsequent schizophrenia in adolescent and young adult offsprings: is there a relationship? Boog, G. Eur. J. Obstet. Gynecol. Reprod. Biol. (2004) [Pubmed]
  10. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Wiley, D.C., Skehel, J.J. Annu. Rev. Biochem. (1987) [Pubmed]
  11. Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import. Martin, K., Helenius, A. Cell (1991) [Pubmed]
  12. Transgenic mice with intracellular immunity to influenza virus. Arnheiter, H., Skuntz, S., Noteborn, M., Chang, S., Meier, E. Cell (1990) [Pubmed]
  13. A role of Ia-associated invariant chains in antigen processing and presentation. Stockinger, B., Pessara, U., Lin, R.H., Habicht, J., Grez, M., Koch, N. Cell (1989) [Pubmed]
  14. Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Staeheli, P., Haller, O., Boll, W., Lindenmann, J., Weissmann, C. Cell (1986) [Pubmed]
  15. Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Weis, W., Brown, J.H., Cusack, S., Paulson, J.C., Skehel, J.J., Wiley, D.C. Nature (1988) [Pubmed]
  16. Influenza virus. Amantadine blocks the channel. Skehel, J.J. Nature (1992) [Pubmed]
  17. Increased viral pathogenicity after insertion of a 28S ribosomal RNA sequence into the haemagglutinin gene of an influenza virus. Khatchikian, D., Orlich, M., Rott, R. Nature (1989) [Pubmed]
  18. Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes. Yewdell, J.W., Bennink, J.R. Science (1989) [Pubmed]
  19. A novel influenza A virus mitochondrial protein that induces cell death. Chen, W., Calvo, P.A., Malide, D., Gibbs, J., Schubert, U., Bacik, I., Basta, S., O'Neill, R., Schickli, J., Palese, P., Henklein, P., Bennink, J.R., Yewdell, J.W. Nat. Med. (2001) [Pubmed]
  20. Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA. Alonso-Caplen, F.V., Nemeroff, M.E., Qiu, Y., Krug, R.M. Genes Dev. (1992) [Pubmed]
  21. Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Franzoso, G., Carlson, L., Scharton-Kersten, T., Shores, E.W., Epstein, S., Grinberg, A., Tran, T., Shacter, E., Leonardi, A., Anver, M., Love, P., Sher, A., Siebenlist, U. Immunity (1997) [Pubmed]
  22. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment. Hayden, F.G., Treanor, J.J., Fritz, R.S., Lobo, M., Betts, R.F., Miller, M., Kinnersley, N., Mills, R.G., Ward, P., Straus, S.E. JAMA (1999) [Pubmed]
  23. Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarization. Cella, M., Facchetti, F., Lanzavecchia, A., Colonna, M. Nat. Immunol. (2000) [Pubmed]
  24. Immune interferon produced to high levels by antigenic stimulation of human lymphocytes with influenza virus. Ennis, F.A., Meager, A. J. Exp. Med. (1981) [Pubmed]
  25. Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus. Respiratory syncytial virus is a potent inducer of inhibitor activity. Roberts, N.J., Prill, A.H., Mann, T.N. J. Exp. Med. (1986) [Pubmed]
  26. Structure-function relationships among highly diverse T cells that recognize a determinant from influenza virus hemagglutinin. Taylor, A.H., Haberman, A.M., Gerhard, W., Caton, A.J. J. Exp. Med. (1990) [Pubmed]
  27. Replacement of the cytoplasmic domain alters sorting of a viral glycoprotein in polarized cells. Puddington, L., Woodgett, C., Rose, J.K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  28. Polarity of influenza and vesicular stomatitis virus maturation in MDCK cells: lack of a requirement for glycosylation of viral glycoproteins. Roth, M.G., Fitzpatrick, J.P., Compans, R.W. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  29. Response to influenza infection in mice with a targeted disruption in the interferon gamma gene. Graham, M.B., Dalton, D.K., Giltinan, D., Braciale, V.L., Stewart, T.A., Braciale, T.J. J. Exp. Med. (1993) [Pubmed]
  30. Suppressed expression of ICAM-1 and LFA-1 and abrogation of leukocyte collaboration after exposure of human mononuclear leukocytes to respiratory syncytial virus in vitro. Comparison with exposure to influenza virus. Salkind, A.R., Nichols, J.E., Roberts, N.J. J. Clin. Invest. (1991) [Pubmed]
  31. Complete nucleotide sequence of the neuraminidase gene of influenza B virus. Shaw, M.W., Lamb, R.A., Erickson, B.W., Briedis, D.J., Choppin, P.W. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  32. Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice. Johnson, B.J., Costelloe, E.O., Fitzpatrick, D.R., Haanen, J.B., Schumacher, T.N., Brown, L.E., Kelso, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  33. Identification of a second interferon-regulated murine Mx gene. Staeheli, P., Sutcliffe, J.G. Mol. Cell. Biol. (1988) [Pubmed]
  34. Immunologic studies on the influenza A virus nonstructural protein NS1. Shaw, M.W., Lamon, E.W., Compans, R.W. J. Exp. Med. (1982) [Pubmed]
  35. Structural features of membrane fusion between influenza virus and liposome as revealed by quick-freezing electron microscopy. Kanaseki, T., Kawasaki, K., Murata, M., Ikeuchi, Y., Ohnishi, S. J. Cell Biol. (1997) [Pubmed]
  36. Influenza vaccination in kidney transplant recipients: cellular and humoral immune responses. Briggs, W.A., Rozek, R.J., Migdal, S.D., Shillis, J.L., Brackett, R.G., Brandon, F.B., Mahajan, S.K., McDonald, F.D. Ann. Intern. Med. (1980) [Pubmed]
  37. Diversity of the antibody response to the different antigenic determinants on the hemagglutinin subunits of influenza viruses. Laver, W.G., Downie, J.C., Webster, R.G. J. Immunol. (1976) [Pubmed]
  38. Induction of antibody responses to influenza virus in human lymphocyte cultures. I. Role of interleukin 2. Tan, P.L., Booth, R.J., Prestidge, R.L., Watson, J.D., Dower, S.K., Gillis, S. J. Immunol. (1985) [Pubmed]
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