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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Visualization of reactive oxygen species formation by phagocytizing macrophages.

Activated peritoneal macrophages exhibiting phagocytosing capacity produced an electron-dense precipitate of formazan in contact sites of macrophage plasmalemma and phagocytosed yeast cells. No production of formazan occurred, when non-opsonized latex particles were ingested by macrophages. Formazan precipitation could be prevented by anaerobiosis but not by addition of cyanide.[1]


  1. Visualization of reactive oxygen species formation by phagocytizing macrophages. Peskin, A.V., Khramtsov, A.V., Morozov, I.A., Zemskov, V.M., Zbarsky, I.B. Exp. Cell Res. (1984) [Pubmed]
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