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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Anaerobiosis

  • Expression of the Escherichia coli dmsABC operon that encodes a molybdenum-containing DMSO/TMAO reductase is increased in response to anaerobiosis and repressed by nitrate [1].
  • These results suggest that enolase expression in maize and E. crus-pavonis during anoxia are similarly regulated at the transcriptional level but differ in posttranslational regulation, whereas enolase is fully induced in E. phyllopogon during anaerobiosis [2].
  • It was demonstrated previously that abrupt transfer of vigorously aerated cultures of Mycobacterium tuberculosis to anaerobic conditions resulted in their rapid death, but gradual depletion of available O2 permitted expression of increased tolerance to anaerobiosis [3].
  • DNA microarrays were used to examine the transcriptional response of Pseudomonas aeruginosa to anaerobiosis and nitrate [4].
  • Like other members of the Clostridium cluster I, subcluster A, A. polyendosporus possesses such common phenotypic features as a Gram-positive cell wall structure, anaerobiosis, derivation of energy from carbohydrate fermentation yielding butyric acid among other organic acids and the capacity for endogenous spore-formation [5].

High impact information on Anaerobiosis

  • A number of environmental stresses (such as osmotic shock and anaerobiosis) have been shown to induce changes in DNA supercoiling that can directly affect the transcription of a specific subset of bacterial genes, at least some of which (the outer-membrane porins and type 1 fimbriae) play a part in bacterial virulence [6].
  • The glucocorticoid receptor binding capacity of rat thymus cells disappears when the cells are depleted of ATP by anaerobiosis, and rapidly reappears when ATP levels are restored [7].
  • Changes in Cai2+ with time can also be followed: exposure of the cells to anaerobiosis or the calcium ionophore A23187 reversibly increases Cai2+ [8].
  • It is also more easily measured and, therefore, more clinically useful than either Q, as a predictor of anaerobiosis and survival, or blood lactate concentration, as a predictor of survival [9].
  • Neither anaerobiosis nor mitochondrial inhibitors substantially protected C. albicans exposed to NP-1, poly-L-arginine, poly-L-lysine, or mellitin [10].

Chemical compound and disease context of Anaerobiosis


Biological context of Anaerobiosis


Anatomical context of Anaerobiosis


Associations of Anaerobiosis with chemical compounds


Gene context of Anaerobiosis

  • Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media [20].
  • We identified 9 genes as responsive to UPC2 that were also induced under anaerobiosis, when sterol uptake is essential [30].
  • Using arcA-lac transcriptional and translational fusions, we show that arcA expression increases (about fourfold) in anaerobiosis and that both Fnr and ArcA are required for full expression [31].
  • Transcription from narXp is not significantly induced by nitrate under anaerobiosis, whereas transcription from narK promoter, which overlaps narXp region and is transcribed divergently, is fully induced by nitrate [32].
  • In addition, psiE-lacZ is negatively controlled by the cAMP and CAP system. psiO-lacZ is induced by phosphate-, carbon- or nitrogen-limited growth or by anaerobiosis [33].

Analytical, diagnostic and therapeutic context of Anaerobiosis


  1. Anaerobic regulation of the Escherichia coli dmsABC operon requires the molybdate-responsive regulator ModE. McNicholas, P.M., Chiang, R.C., Gunsalus, R.P. Mol. Microbiol. (1998) [Pubmed]
  2. Identification and gene expression of anaerobically induced enolase in Echinochloa phyllopogon and Echinochloa crus-pavonis. Fox, T.C., Mujer, C.V., Andrews, D.L., Williams, A.S., Cobb, B.G., Kennedy, R.A., Rumpho, M.E. Plant Physiol. (1995) [Pubmed]
  3. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Wayne, L.G., Hayes, L.G. Infect. Immun. (1996) [Pubmed]
  4. Effect of anaerobiosis and nitrate on gene expression in Pseudomonas aeruginosa. Filiatrault, M.J., Wagner, V.E., Bushnell, D., Haidaris, C.G., Iglewski, B.H., Passador, L. Infect. Immun. (2005) [Pubmed]
  5. Phylogenetic status of Anaerobacter polyendosporus, an anaerobic, polysporogenic bacterium. Siunov, A.V., Nikitin, D.V., Suzina, N.E., Dmitriev, V.V., Kuzmin, N.P., Duda, V.I. Int. J. Syst. Bacteriol. (1999) [Pubmed]
  6. DNA supercoiling and environmental regulation of virulence gene expression in Shigella flexneri. Dorman, C.J., Bhriain, N.N., Higgins, C.F. Nature (1990) [Pubmed]
  7. Glucocorticoid receptors lacking hormone-binding activity are bound in nuclei of ATP-depleted cells. Mendel, D.B., Bodwell, J.E., Munck, A. Nature (1986) [Pubmed]
  8. Measurement of intracellular free calcium in monkey kidney cells with aequorin. Borle, A.B., Snowdowne, K.W. Science (1982) [Pubmed]
  9. Mixed venous oxygen tension and hyperlactatemia. Survival in severe cardiopulmonary disease. Kasnitz, P., Druger, G.L., Yorra, F., Simmons, D.H. JAMA (1976) [Pubmed]
  10. Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. Lehrer, R.I., Ganz, T., Szklarek, D., Selsted, M.E. J. Clin. Invest. (1988) [Pubmed]
  11. Transport of vitamin B12 in Escherichia coli: energy dependence. Bradbeer, C., Woodrow, M.L. J. Bacteriol. (1976) [Pubmed]
  12. Cloning, nucleotide sequence, and transcriptional analysis of the Pediococcus acidilactici L-(+)-lactate dehydrogenase gene. Garmyn, D., Ferain, T., Bernard, N., Hols, P., Delcour, J. Appl. Environ. Microbiol. (1995) [Pubmed]
  13. Identification and characterization of the caiF gene encoding a potential transcriptional activator of carnitine metabolism in Escherichia coli. Eichler, K., Buchet, A., Lemke, R., Kleber, H.P., Mandrand-Berthelot, M.A. J. Bacteriol. (1996) [Pubmed]
  14. Membrane protein expression by Actinobacillus actinomycetemcomitans in response to iron availability. Winston, J.L., Chen, C.K., Neiders, M.E., Dyer, D.W. J. Dent. Res. (1993) [Pubmed]
  15. Effects of T4 phage infection and anaerobiosis upon nucleotide pools and mutagenesis in nucleoside diphosphokinase-defective Escherichia coli strains. Zhang, X., Lu, Q., Inouye, M., Mathews, C.K. J. Bacteriol. (1996) [Pubmed]
  16. Anaerobic transcription activation in Bacillus subtilis: identification of distinct FNR-dependent and -independent regulatory mechanisms. Cruz Ramos, H., Boursier, L., Moszer, I., Kunst, F., Danchin, A., Glaser, P. EMBO J. (1995) [Pubmed]
  17. Down-regulation of tumor necrosis factor receptors by blockade of mitochondrial respiration. Sánchez-Alcázar, J.A., Hernández, I., De la Torre, M.P., García, I., Santiago, E., Muñoz-Yagüe, M.T., Solís-Herruzo, J.A. J. Biol. Chem. (1995) [Pubmed]
  18. Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes. Rodríguez-Manzaneque, M.T., Tamarit, J., Bellí, G., Ros, J., Herrero, E. Mol. Biol. Cell (2002) [Pubmed]
  19. SUT1p interaction with Cyc8p(Ssn6p) relieves hypoxic genes from Cyc8p-Tup1p repression in Saccharomyces cerevisiae. Régnacq, M., Alimardani, P., El Moudni, B., Bergès, T. Mol. Microbiol. (2001) [Pubmed]
  20. Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Lai, L.C., Kosorukoff, A.L., Burke, P.V., Kwast, K.E. Mol. Cell. Biol. (2005) [Pubmed]
  21. Mitochondrial inclusions in human cancer of the gastrointestinal tract. Marinozzi, V., Derenzini, M., Nardi, F., Gallo, P. Cancer Res. (1977) [Pubmed]
  22. Mycobacterium tuberculosis uptake by recipient host macrophages is influenced by environmental conditions in the granuloma of the infectious individual and is associated with impaired production of interleukin-12 and tumor necrosis factor alpha. Li, Y.J., Petrofsky, M., Bermudez, L.E. Infect. Immun. (2002) [Pubmed]
  23. Protein synthesis in salivary glands of Drosophila hydei after experimental gene induction. Koninkx, J.F. Biochem. J. (1976) [Pubmed]
  24. Activation of tyrosine hydroxylase in the central nervous system by anaerobiosis. Pastuszko, A., Wilson, D.F., Erecińska, M. Biochem. Pharmacol. (1985) [Pubmed]
  25. Extracellular proton release by stimulated neutrophils. van Zwieten, R., Wever, R., Hamers, M.N., Weening, R.S., Roos, D. J. Clin. Invest. (1981) [Pubmed]
  26. Energy metabolisms of parasitic helminths: adaptations to parasitism. Saz, H.J. Annu. Rev. Physiol. (1981) [Pubmed]
  27. Energy-dependent intracellular translocation of proparathormone. Chu, L.L., MacGregor, R.R., Cohn, D.V. J. Cell Biol. (1977) [Pubmed]
  28. K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells. Margolis, L.B., Novikova I, Y., Rozovskaya, I.A., Skulachev, V.P. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  29. Complex transcriptional regulation of the Saccharomyces cerevisiae CYB2 gene encoding cytochrome b2: CYP1(HAP1) activator binds to the CYB2 upstream activation site UAS1-B2. Lodi, T., Guiard, B. Mol. Cell. Biol. (1991) [Pubmed]
  30. Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. Wilcox, L.J., Balderes, D.A., Wharton, B., Tinkelenberg, A.H., Rao, G., Sturley, S.L. J. Biol. Chem. (2002) [Pubmed]
  31. Anaerobic activation of arcA transcription in Escherichia coli: roles of Fnr and ArcA. Compan, I., Touati, D. Mol. Microbiol. (1994) [Pubmed]
  32. The narX and narL genes encoding the nitrate-sensing regulators of Escherichia coli are homologous to a family of prokaryotic two-component regulatory genes. Nohno, T., Noji, S., Taniguchi, S., Saito, T. Nucleic Acids Res. (1989) [Pubmed]
  33. Overlapping and separate controls on the phosphate regulon in Escherichia coli K12. Wanner, B.L. J. Mol. Biol. (1983) [Pubmed]
  34. A randomized comparison of crystalloid and blood-containing cardioplegic solutions in 60 patients. Buttner, E.E., Karp, R.B., Reves, J.G., Oparil, S., Brummett, C., McDaniel, H.G., Smith, L.R., Kreusch, G. Circulation (1984) [Pubmed]
  35. Tissue oxygenation in low flow states and during hypoxemia. Grum, C.M. Crit. Care Med. (1993) [Pubmed]
  36. Expression of R-plasmid functions during anaerobic growth of an Escherichia coli K-12 host. Burman, L.G. J. Bacteriol. (1977) [Pubmed]
  37. Anaerobic metabolism of the common cockle, Cardium edule. I.--The utilization of glycogen and accumulation of multiple end products. Gäde, G. Arch. Int. Physiol. Biochim. (1975) [Pubmed]
  38. The influence of oxygen deficiency and electrical stimulation on the concentrations of ATP, ADP, AMP and phosphotaurocyamine in the body-wall musculature of Arenicola marina. Surholt, B. Hoppe-Seyler's Z. Physiol. Chem. (1977) [Pubmed]
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