Effect of diisopropyl 1,3-dithiolan-2-ylidenemalonate on experimental fatty livers in chicks.
The effect of diisopropyl 1,3-dithiolan-2-ylidenemalonate (NKK-100) on experimental fatty livers was investigated in chicks administered an antithyroid agent plus synthetic estrogen or in estrogenized, starved-refed chicks. NKK-100 was added at levels of 250, 500, 1000, and 1500 mg/kg diet. Liver weight was significantly decreased by administration of NKK-100 at 1500 mg/kg diet in the estrogen-administered chicks. Liver lipid content and liver lipid deposition were significantly and inversely decreased with increasing NKK-100 concentration in the diet in the estrogen administered chicks. Plasma transaminase activity, which was elevated by the estrogen administration, was reduced by the administration of NKK-100. These results suggest that NKK-100 may be of value in preventing fatty livers in poultry.[1]References
- Effect of diisopropyl 1,3-dithiolan-2-ylidenemalonate on experimental fatty livers in chicks. Akiba, Y., Takahashi, K., Matsumoto, T. Poult. Sci. (1984) [Pubmed]
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