Disease relevance of Fudiolan

• These results suggest that NKK-100 may be of value in preventing fatty livers in poultry [1].
• Therapeutic effect of isoprothiolane on bovine fat necrosis [2].

High impact information on Fudiolan

• 1. The herbicides butachlor (2-chloro-2',6',diethyl-N-[buthoxymethyl] acetanilide) and pretilachlor (2-chloro-2',6'-diethyl-N-[2-propoxyethyl] acetanilide) are widely used in Asia, South America, Europe and Africa. Isoprothiolane (diisopropyl-1,3-dithiolan-2-ylidenemalonate) is used as a fungicide and an insecticide in rice paddies [3].
• Hepatotoxicity of diisopropyl ester of malonic acid and chloromalonic acids, disinfection by-products of the fungicide isoprothiolane [4].
• This study was performed to investigate the effects of isoprothiolane on cell growth and the production of interleukin (IL)-1 and IL-6 by bovine mammary epithelial cells in vitro [5].
• These results indicated that isoprothiolane regulated mammary epithelial cell growth in vitro possibly by modulating the production of cytokines [5].
• It is suggested that isoprothiolane produces an improvement in hepatic lipid metabolism including acceleration of plasma NEFA uptake and alpha-lipoprotein secretion in affected cows [6].

Chemical compound and disease context of Fudiolan

• To study effects of isoprothiolane and phytosterol on dietary fat necrosis, 3 groups of rats were fed hardened-tallow (HT) diet [7].

Biological context of Fudiolan

• Effects of isoprothiolane on cell growth of cultured bovine mammary epithelial cells [5].

Anatomical context of Fudiolan

• Isoprothiolane increased proliferation of mammary epithelial cells in a dose-dependent manner at the concentration of 0.05 to 5 microM when cultured either with or without serum-supplemented medium [5].
• Basal [U-14C]glucose conversion rate to total lipids in isolated adipocytes of the rats was significantly decreased by treatment with isoprothiolane (54%) or phytosterol (82%) [8].
• Isoprothiolane did not promote the activity of the demethylase and hydroxylase in liver microsomes but it promoted the formation of cytochrome P-450 and b5 whose contents in the animals treated with isoprothiolane of a dose of 50 or 100 mg/kg were about twice as high as those in the non-treated animals [9].

Associations of Fudiolan with other chemical compounds

• Adipocytes from the rats with isoprothiolane released less glycerol than those from control rats only at an epinephrine concentration of 10 microM [8].

Gene context of Fudiolan

• The PHP-LPL activity in the affected cows was significantly (P < 0.001) higher than in normal animals and tended to reduce 4 weeks after treatment with isoprothiolane [6].

References