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Chemical Compound Review

Fudiolan     dipropan-2-yl 2-(1,3-dithiolan-2...

Synonyms: Fujione, ISOPROTHIOLANE, Fuji-one, Fuji 1, PT (pesticide), ...
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Disease relevance of Fudiolan


High impact information on Fudiolan


Chemical compound and disease context of Fudiolan


Biological context of Fudiolan


Anatomical context of Fudiolan

  • Isoprothiolane increased proliferation of mammary epithelial cells in a dose-dependent manner at the concentration of 0.05 to 5 microM when cultured either with or without serum-supplemented medium [5].
  • Basal [U-14C]glucose conversion rate to total lipids in isolated adipocytes of the rats was significantly decreased by treatment with isoprothiolane (54%) or phytosterol (82%) [8].
  • Isoprothiolane did not promote the activity of the demethylase and hydroxylase in liver microsomes but it promoted the formation of cytochrome P-450 and b5 whose contents in the animals treated with isoprothiolane of a dose of 50 or 100 mg/kg were about twice as high as those in the non-treated animals [9].

Associations of Fudiolan with other chemical compounds


Gene context of Fudiolan


  1. Effect of diisopropyl 1,3-dithiolan-2-ylidenemalonate on experimental fatty livers in chicks. Akiba, Y., Takahashi, K., Matsumoto, T. Poult. Sci. (1984) [Pubmed]
  2. Therapeutic effect of isoprothiolane on bovine fat necrosis. Shimada, Y., Katamoto, H., Ishida, S., Kobayashi, K., Tohzyoh, H. Nippon Juigaku Zasshi (1988) [Pubmed]
  3. Effects of the agrochemicals butachlor, pretilachlor and isoprothiolane on rat liver xenobiotic-metabolizing enzymes. Ishizuka, M., Iwata, H., Kazusaka, A., Hatakeyama, S., Fujita, S. Xenobiotica (1998) [Pubmed]
  4. Hepatotoxicity of diisopropyl ester of malonic acid and chloromalonic acids, disinfection by-products of the fungicide isoprothiolane. Jinno, H., Hanioka, N., Nishikawa, S., Yoda, R., Toyo'oka, T., Nishimura, T., Ando, M. Arch. Toxicol. (1997) [Pubmed]
  5. Effects of isoprothiolane on cell growth of cultured bovine mammary epithelial cells. Okada, H., Miyake, Y., Ohtsuka, H., Kiku, Y., Fukuda, S., Watanabe, A., Yokomizo, Y., Rosol, T.J., Yoshino, T. J. Vet. Med. Sci. (1999) [Pubmed]
  6. Lipoprotein lipase activity of post-heparin plasma in Japanese black cattle affected with fat necrosis. Katamoto, H., Aoki, M., Shimada, Y., Hakogi, E. Br. Vet. J. (1996) [Pubmed]
  7. Effects of isoprothiolane and phytosterol on lipogenesis and lipolysis in adipocytes from rats of dietary fat necrosis. Katamoto, H., Kurihara, S., Shimada, Y. Nippon Juigaku Zasshi (1990) [Pubmed]
  8. Effects of isoprothiolane and phytosterol on adipocyte metabolism and fatty acid composition of serum and tissue lipids in rats. Katamoto, H., Yoneda, N., Shimada, Y. J. Vet. Med. Sci. (1991) [Pubmed]
  9. Effect of isoprothiolane on hepatic lesions of heifer caused by carbon tetrachloride. Nagasawa, S., Yamanaka, H., Motoi, Y., Ishikawa, T., Takizawa, T. Nippon Juigaku Zasshi (1989) [Pubmed]
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