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Chemical Compound Review

Biisopropyl     2,3-dimethylbutane

Synonyms: Diisopropyl, HSDB 76, AGN-PC-0CJY9T, ACMC-1BMFQ, CCRIS 6020, ...
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Disease relevance of Diisopropyl


Psychiatry related information on Diisopropyl


High impact information on Diisopropyl


Chemical compound and disease context of Diisopropyl


Biological context of Diisopropyl


Anatomical context of Diisopropyl

  • Flow cytometry of neutrophils saturated with exogenous diisopropyl fluorophosphate-uPA shows a large excess (approximately 90%) of unoccupied uPAR on resting as well as FMLP- and PMA-stimulated neutrophils, suggesting a possible role for exogenous pro-uPA in providing neutrophils with a potential for plasminogen activation [21].
  • Mesangial cells rapidly converted exogenous [3H]PAF to [3H]lyso-PAF and 1-O-[3H]alkyl-2-acyl-GPC, and this process was inhibited by diisopropyl fluorophosphate (10 microM) [22].
  • Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i. Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i. Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells [23].
  • The two activities in rat adipose tissue were associated as judged by their co-elution profiles, co-purifications at different steps, co-precipitations by antibody raised against purified FAEE synthase, and identical profiles of inhibition by diisopropyl fluorophosphate [24].
  • Pretreatment of neutrophils, HL60 cells, or a recombinant fucosylated soluble form of PSGL-1 (sPSGL-1.T7) with the cobra venom metalloproteinase, mocarhagin, completely abolished binding to purified P-selectin in a time-dependent and EDTA- and diisopropyl fluorophosphate-inhibitable manner consistent with mocarhagin selectively cleaving PSGL-1 [25].

Associations of Diisopropyl with other chemical compounds


Gene context of Diisopropyl


Analytical, diagnostic and therapeutic context of Diisopropyl


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  2. Increased Enantioselectivity and Remarkable Acceleration of Lipase-Catalyzed Transesterification by Using an Imidazolium PEG-Alkyl Sulfate Ionic Liquid. Itoh, T., Matsushita, Y., Abe, Y., Han, S.H., Wada, S., Hayase, S., Kawatsura, M., Takai, S., Morimoto, M., Hirose, Y. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
  3. In vitro killing of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. by human neutrophil cathepsin G and elastase. Miyasaki, K.T., Bodeau, A.L. Infect. Immun. (1991) [Pubmed]
  4. Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity. Auta, J., Costa, E., Davis, J., Guidotti, A. Neuropharmacology (2004) [Pubmed]
  5. Mechanisms of respiratory failure produced by neostigmine and diisopropyl fluorophosphate. Fleming, N.W., Henderson, T.R., Dretchen, K.L. Eur. J. Pharmacol. (1991) [Pubmed]
  6. The effects of diisopropyl phosphorofluoridate (DFP) on time perception in rats. Raslear, T.G., Shurtleff, D., Simmons, L. Physiol. Behav. (1988) [Pubmed]
  7. Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo. Schwartz, R.D., Kellar, K.J. Science (1983) [Pubmed]
  8. Hydrolysis of nerve gas by squid-type diisopropyl phosphorofluoridate hydrolyzing enzyme on agarose resin. Hoskin, F.C., Roush, A.H. Science (1982) [Pubmed]
  9. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. Pereira, H.A., Shafer, W.M., Pohl, J., Martin, L.E., Spitznagel, J.K. J. Clin. Invest. (1990) [Pubmed]
  10. Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants. Stephens, R.W., Pöllänen, J., Tapiovaara, H., Leung, K.C., Sim, P.S., Salonen, E.M., Rønne, E., Behrendt, N., Danø, K., Vaheri, A. J. Cell Biol. (1989) [Pubmed]
  11. The D-galactosamine loaded mouse and its enhanced sensitivity to lipopolysaccharide and monophosphoryl lipid A: a role for superoxide. Elliott, G.T., Welty, D., Kuo, Y.D. J. Immunother. (1991) [Pubmed]
  12. Use of C1300 neuroblastoma cells to evaluate the protective value of hexamethonium, trimethaphan, hemicholinium, and triethylcholine against diisopropyl phosphorofluoridate toxicity. Hong, S.J., Rohde, B.H., Chiou, G.C. Journal of pharmaceutical sciences. (1995) [Pubmed]
  13. Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments. Cardoso, V.M., Solano, A.G., Prado, M.A., Nunan, E.d.e. .A. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
  14. Effect of diisopropyl 1,3-dithiol-2-ylidenemalonate (NKK-105) on fatty liver induced by carbon tetrachloride. Imaizumi, Y., Sugimoto, T., Kasai, T. Jpn. J. Pharmacol. (1981) [Pubmed]
  15. Delayed excretion of radionuclide in scanning with diisopropyl iminodiacetic acid does not exclude the possibility of primary biliary atresia: case report. Clarke, B., O'Donovan, A.N., Coates, G. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. (1997) [Pubmed]
  16. Association of a protease with polytene chromosomes of Drosophila melanogaster. Cavagnaro, J., Pierce, D.A., Lucchesi, J.C., Chae, C.B. J. Cell Biol. (1980) [Pubmed]
  17. Physiologic oxygen tensions limit oxidant-mediated killing of schistosome eggs by inflammatory cells and isolated granulomas. Feldman, G.M., Dannenberg, A.M., Seed, J.L. J. Leukoc. Biol. (1990) [Pubmed]
  18. Neutrophil chemotaxis by Propionibacterium acnes lipase and its inhibition. Lee, W.L., Shalita, A.R., Suntharalingam, K., Fikrig, S.M. Infect. Immun. (1982) [Pubmed]
  19. Modification of near active site residues in organophosphorus hydrolase reduces metal stoichiometry and alters substrate specificity. diSioudi, B., Grimsley, J.K., Lai, K., Wild, J.R. Biochemistry (1999) [Pubmed]
  20. Retention of gangliosides in serum delipidated by diisopropyl ether-1-butanol extraction. Wong, C.G., Ladisch, S. J. Lipid Res. (1983) [Pubmed]
  21. The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils. Plesner, T., Ploug, M., Ellis, V., Rønne, E., Høyer-Hansen, G., Wittrup, M., Pedersen, T.L., Tscherning, T., Danø, K., Hansen, N.E. Blood (1994) [Pubmed]
  22. Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells. Lianos, E.A., Zanglis, A. J. Biol. Chem. (1987) [Pubmed]
  23. Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production. Mari, B., Imbert, V., Belhacene, N., Far, D.F., Peyron, J.F., Pouysségur, J., Van Obberghen-Schilling, E., Rossi, B., Auberger, P. J. Biol. Chem. (1994) [Pubmed]
  24. Fatty acid ethyl ester synthase in rat adipose tissue and its relationship to carboxylesterase. Tsujita, T., Okuda, H. J. Biol. Chem. (1992) [Pubmed]
  25. A novel cobra venom metalloproteinase, mocarhagin, cleaves a 10-amino acid peptide from the mature N terminus of P-selectin glycoprotein ligand receptor, PSGL-1, and abolishes P-selectin binding. De Luca, M., Dunlop, L.C., Andrews, R.K., Flannery, J.V., Ettling, R., Cumming, D.A., Veldman, G.M., Berndt, M.C. J. Biol. Chem. (1995) [Pubmed]
  26. Partial sequence of human complement component factor B: novel type of serine protease. Christie, D.L., Gagnon, J., Porter, R.R. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  27. Proteolytic cleavage of single-chain pro-urokinase induces conformational change which follows activation of the zymogen and reduction of its high affinity for fibrin. Kasai, S., Arimura, H., Nishida, M., Suyama, T. J. Biol. Chem. (1985) [Pubmed]
  28. A novel kinin-generating protease (kininogenase) in the porcine anterior pituitary. Powers, C.A., Nasjletti, A. J. Biol. Chem. (1982) [Pubmed]
  29. The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors. Ordentlich, A., Barak, D., Kronman, C., Ariel, N., Segall, Y., Velan, B., Shafferman, A. J. Biol. Chem. (1996) [Pubmed]
  30. Chrysobactin-dependent iron acquisition in Erwinia chrysanthemi. Functional study of a homolog of the Escherichia coli ferric enterobactin esterase. Rauscher, L., Expert, D., Matzanke, B.F., Trautwein, A.X. J. Biol. Chem. (2002) [Pubmed]
  31. The endothelial cell tissue plasminogen activator receptor. Specific interaction with plasminogen. Hajjar, K.A. J. Biol. Chem. (1991) [Pubmed]
  32. Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV. Bjelke, J.R., Christensen, J., Branner, S., Wagtmann, N., Olsen, C., Kanstrup, A.B., Rasmussen, H.B. J. Biol. Chem. (2004) [Pubmed]
  33. Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. Piñeiro-Sánchez, M.L., Goldstein, L.A., Dodt, J., Howard, L., Yeh, Y., Tran, H., Argraves, W.S., Chen, W.T. J. Biol. Chem. (1997) [Pubmed]
  34. Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses. Hancock, W.W., Grey, S.T., Hau, L., Akalin, E., Orthner, C., Sayegh, M.H., Salem, H.H. Transplantation (1995) [Pubmed]
  35. Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa B and activator protein-1 in human monocytes. Yuksel, M., Okajima, K., Uchiba, M., Horiuchi, S., Okabe, H. Thromb. Haemost. (2002) [Pubmed]
  36. Acyl-peptide hydrolase from rat liver. Characterization of enzyme reaction. Kobayashi, K., Smith, J.A. J. Biol. Chem. (1987) [Pubmed]
  37. Structurally distinctive vasoactive intestinal peptides from rat basophilic leukemia cells. Goetzl, E.J., Sreedharan, S.P., Turck, C.W. J. Biol. Chem. (1988) [Pubmed]
  38. Localization of urokinase-type plasminogen activator receptor on U937 cells: phorbol ester PMA induces heterogeneity. Hansen, S.H., Behrendt, N., Danø, K., Kristensen, P. Exp. Cell Res. (1990) [Pubmed]
  39. Degradation of coagulation proteins by an enzyme from Malayan pit viper (Akistrodon rhodostoma) venom. Lollar, P., Parker, C.G., Kajenski, P.J., Litwiller, R.D., Fass, D.N. Biochemistry (1987) [Pubmed]
  40. Distinct muscarinic receptor subtypes differentially modulate acetylcholine release from corticocerebral synaptosomes. Pittel, Z., Heldman, E., Rubinstein, R., Cohen, S. J. Neurochem. (1990) [Pubmed]
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