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Chemical Compound Review

Biisopropyl     2,3-dimethylbutane

Synonyms: Diisopropyl, HSDB 76, AGN-PC-0CJY9T, ACMC-1BMFQ, CCRIS 6020, ...
 
 
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Disease relevance of Diisopropyl

 

Psychiatry related information on Diisopropyl

 

High impact information on Diisopropyl

 

Chemical compound and disease context of Diisopropyl

 

Biological context of Diisopropyl

 

Anatomical context of Diisopropyl

  • Flow cytometry of neutrophils saturated with exogenous diisopropyl fluorophosphate-uPA shows a large excess (approximately 90%) of unoccupied uPAR on resting as well as FMLP- and PMA-stimulated neutrophils, suggesting a possible role for exogenous pro-uPA in providing neutrophils with a potential for plasminogen activation [21].
  • Mesangial cells rapidly converted exogenous [3H]PAF to [3H]lyso-PAF and 1-O-[3H]alkyl-2-acyl-GPC, and this process was inhibited by diisopropyl fluorophosphate (10 microM) [22].
  • Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [Ca2+]i. Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [Ca2+]i. Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [Ca2+]i rise in Jurkat T cells [23].
  • The two activities in rat adipose tissue were associated as judged by their co-elution profiles, co-purifications at different steps, co-precipitations by antibody raised against purified FAEE synthase, and identical profiles of inhibition by diisopropyl fluorophosphate [24].
  • Pretreatment of neutrophils, HL60 cells, or a recombinant fucosylated soluble form of PSGL-1 (sPSGL-1.T7) with the cobra venom metalloproteinase, mocarhagin, completely abolished binding to purified P-selectin in a time-dependent and EDTA- and diisopropyl fluorophosphate-inhibitable manner consistent with mocarhagin selectively cleaving PSGL-1 [25].
 

Associations of Diisopropyl with other chemical compounds

 

Gene context of Diisopropyl

 

Analytical, diagnostic and therapeutic context of Diisopropyl

References

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  4. Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity. Auta, J., Costa, E., Davis, J., Guidotti, A. Neuropharmacology (2004) [Pubmed]
  5. Mechanisms of respiratory failure produced by neostigmine and diisopropyl fluorophosphate. Fleming, N.W., Henderson, T.R., Dretchen, K.L. Eur. J. Pharmacol. (1991) [Pubmed]
  6. The effects of diisopropyl phosphorofluoridate (DFP) on time perception in rats. Raslear, T.G., Shurtleff, D., Simmons, L. Physiol. Behav. (1988) [Pubmed]
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  15. Delayed excretion of radionuclide in scanning with diisopropyl iminodiacetic acid does not exclude the possibility of primary biliary atresia: case report. Clarke, B., O'Donovan, A.N., Coates, G. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. (1997) [Pubmed]
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