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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The prognostic value of noninvasive CBF measurement in subarachnoid hemorrhage.

Seventy-four measurements of cerebral blood flow (CBF) were performed using the Xenon 133 inhalation method in 50 cases of spontaneous subarachnoid hemorrhage. This method is non-traumatic, reproducible and dependable. A correlation was found between clinical condition and CBF values, but in a number of cases which cannot be dismissed, very low mean CBF values or ischemic foci were revealed where clinical state gave no indication of same. A poor correlation appeared between vasospasm seen by angiography and ischemic foci detected by isotopic technique. Patients' age influenced CBF values but not clinical evolution. CBF values, measured in the first two weeks of illness, were significantly higher in those patients having favorable outcome, whatever their clinical state at the time of CBF measurement (comas excluded). The figure of 60 ml/100g/min. for mean cortical flow seemed to be a critical level below which risk of complications was greater. Conversely, in every case where mean cortical flow measured above 70 ml, outcome was favorable. Thus, CBF measurement promises to be a valuable prognostic tool, playing an important role in the therapeutic strategy for this type of patient.[1]


  1. The prognostic value of noninvasive CBF measurement in subarachnoid hemorrhage. Géraud, G., Tremoulet, M., Guell, A., Bes, A. Stroke (1984) [Pubmed]
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