Conjugation of 1-naphthol by human bronchus and bronchoscopy samples.
Human bronchus, in short-term explant culture, metabolized 1-naphthol to both its sulphate ester and glucuronic acid conjugates. At low concentrations of 1-naphthol (20 microM), more 1-naphthyl sulphate than 1-naphthyl-beta-D-glucuronide was formed. At similar substrate concentrations, short-term explant cultures of both bronchus without cartilage and bronchoscopy samples, which consisted largely of bronchial epithelium, formed predominantly 1-naphthyl-beta-D-glucuronide. Thus cartilage, which alone did not significantly metabolize 1-naphthol, may in some way influence the metabolism of 1-naphthol by intact bronchus. A large inter-individual variation was observed in the conjugation of 1-naphthol by cultured human bronchus. Such variations in the conjugation of chemicals may be of importance in determining individual susceptibility to chemically induced damage.[1]References
- Conjugation of 1-naphthol by human bronchus and bronchoscopy samples. Gibby, E.M., Cohen, G.M. Biochem. Pharmacol. (1984) [Pubmed]
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