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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cephalothin prophylaxis for midtrimester abortion.

A randomized prospective double-blind study was conducted to determine the efficacy of prophylactic antibiotics as compared with placebo in 198 women undergoing second-trimester intraamniotic injection abortions. Patients received either sodium cephalothin or placebo intravenously before the procedure and for up to 8 additional doses. In 11 patients postabortion endometritis developed; 2 had received the antibiotic and 9 had received a placebo (P less than .05). Prophylactic cephalothin decreased the incidence of endometritis in patients undergoing midtrimester injection abortion. An injection-abortion interval greater than 24 hours appears to identify patients at risk for the development of postabortion endometritis.[1]


  1. Cephalothin prophylaxis for midtrimester abortion. Spence, M.R., King, T.M., Burkman, R.T., Atienza, M.F. Obstetrics and gynecology. (1982) [Pubmed]
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