Disease relevance of Endometritis

• Aztreonam, a new monobactam antibiotic with specific gram-negative aerobic activity, was used in combination with clindamycin in the treatment of 40 women with pelvic infection, including post-partum endometritis, pelvic inflammatory disease, and post-hysterectomy pelvic cellulitis [1].
• Purulent endometritis was induced by E. coli in ovariectomized rats receiving progesterone or corn oil (hormone vehicle) [2].
• In addition, women with chlamydial cervicitis, histologically confirmed endometritis, and laparoscopically documented salpingitis had CA-125 levels that were not significantly different from those of controls [3].
• Analysis of chronic endometritis for Chlamydia trachomatis by polymerase chain reaction [4].
• CONCLUSION: Endocervical placement of 0.5 mg of PGE2 gel does not increase the incidence of clinical amnionitis and endometritis in patients with PROM at term when compared with immediate induction of labor with oxytocin [5].

Psychiatry related information on Endometritis

• The results of this study suggest that digital cervical examinations in patients with preterm PROM should be avoided until the clinician is convinced that the patient is clearly in labor because digital cervical examinations increase the incidence of chorioamnionitis and endometritis but have no effect on latency period [6].

High impact information on Endometritis

• Treatment successes for endometritis included 42 of 50 (84 percent) patients treated with ciprofloxacin compared with 35 of 47 (75 percent) treated with the clindamycin-gentamicin combination [7].
• A new single-antibiotic combination of ticarcillin and clavulanic acid was compared with the standard two-drug regimen of clindamycin and gentamicin in the treatment of post-cesarean endomyometritis [8].
• Comparative clinical evaluation of ticarcillin plus clavulanic acid versus clindamycin plus gentamicin in treatment of post-cesarean endomyometritis [8].
• This study suggests that the single-drug combination of ticarcillin plus clavulanic acid is effective in the treatment of post-cesarean endomyometritis when compared with the standard regimen of clindamycin and gentamicin [8].
• 400 patients aged 18 to 71 years took part in a multicentre noncomparative study designed to assess the clinical efficacy and tolerability of nimesulide in gynaecological inflammatory disease: adnexitis (72 patients), cervicitis (78 patients), endometritis (18 patients), myometritis (22 patients), and combined disorders (210 patients) [9].

Chemical compound and disease context of Endometritis

• In this tudy, moxalactam was similar in efficacy and, despite its higher acquistion cost, was comparable in total hospital costs and patient charges to clindamycin plus gentacmicin in treating endomyometritis [10].
• A randomized, double-blind regimen of either piperacillin or cefoxitin was equally successful in treating the postpartum endometritis [11].
• Treatment of post-partum endometritis with cefoxitin sodium [12].
• In contrast to controls, ascending infection resulting in endometritis was found in animals receiving doses of greater than or equal to 1.0 microgram of estradiol per day [13].
• Incident PID over a median of 3 years was diagnosed by either histologic endometritis or Centers for Disease Control and Prevention criteria [14].

Biological context of Endometritis

• OBJECTIVE: To estimate prospectively whether reducing oral doxycycline prophylaxis from 7 to 3 days increases the incidence of endometritis after elective first-trimester vacuum abortion [15].
• Prophylactic cephalothin decreased the incidence of endometritis in patients undergoing midtrimester injection abortion [16].
• Effect of repeated administration of PGF2alpha in the early post partum period on the prevalence of clinical endometritis and probability of pregnancy at first insemination in lactating dairy cows [17].
• Comparative pharmacokinetics of once daily intravenous and intramuscular gentamicin in patients with post partum endometritis [18].

Anatomical context of Endometritis

• The Centers for Disease Control and Prevention minimal diagnostic criteria for pelvic inflammatory disease had a sensitivity of 33% for plasma cell endometritis [19].
• Two hundred thirty-one patients developed postpartum endometritis, and the isolates obtained from the endometrium were tested for sensitivity to ampicillin, cefuroxime, ofloxacin, ciprofloxacin, and clindamycin [20].
• Patients of low socioeconomic status undergoing cesarean section who have had prolonged labor and rupture of membranes (ROM) incur a 40 to 85% risk of endometritis [21].
• A first-generation cephalosporin was routinely administered after umbilical cord clamping for prophylaxis of post-cesarean endometritis [22].
• Absorption of neomycin from the equine uterus: effect of bacterial and chemical endometritis [23].

Gene context of Endometritis

• The frequent isolation of beta-lactamase-producing bacteria from patients with postpartum endometritis raises concern about the use of antibiotics not resistant to these enzymes [24].
• Prevalence of beta-lactamase enzyme production in bacteria isolated from women with postpartum endometritis [24].
• Plasma cells in chronic endometritis are easily identified when stained with syndecan-1 [25].
• The results showed that although endometritis is an important manifestation of acute salpingitis, there is no correlation between severity of endometritis and degree of tubal damage [26].
• Postpartum endometritis was more common in HIV-1-infected women than in seronegative controls (10.3 versus 4.2%; P = .01) and was inversely correlated with the CD4 percentage [27].

Analytical, diagnostic and therapeutic context of Endometritis

• Prospective cost analysis of moxalactam versus clindamycin plus gentamicin for endomyometritis after cesarean section [10].
• Cesarean prophylaxis: a comparison of cefamandole and cefazolin by both intravenous and lavage routes, and risk factors associated with endometritis [28].
• Serum gentamicin levels were measured by agar diffusion bioassay in 38 patients undergoing treatment with clindamycin-gentamicin for post-cesarean endomyometritis [29].
• Randomized, double-blind study of cefotetan and cefoxitin in post-cesarean section endometritis [30].
• Ticarcillin/clavulanic acid versus clindamycin and gentamicin in the treatment of post-cesarean endometritis following antibiotic prophylaxis [31].

References