The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A role for estrogen in progesterone production during baboon pregnancy.

The present study determined whether estrogen is important in the production of progesterone (P) during primate pregnancy. Serum P production rates (metabolic clearance rate [MCR] x peripheral serum concentration) were determined in baboons prior to and following maternal administration of the antiestrogen ethamoxytriphetol (MER-25) at 30, 15, 6, or 3 mg/kg of body weight by mouth daily for 10 or 20 day periods during or throughout the last one third of gestation. Maternal peripheral serum P concentrations decreased (p less than 0.05 to P less than 0.001, t test) 37 to 60% in 7 of 9 baboons following daily administration of MER-25. Since mean MCR-P prior to (1,567 1/day) and following (1,361 1/day) MER-25 were similar, the decline in serum P concentration reflected decreased P production. Serum P concentrations in five untreated baboons during the last one third of gestation fluctuated in level, but no significant sequential rise or fall occurred. The decrease in P production in baboons following antiestrogen administration suggests that the action of estrogen is required for sustaining the elevated P production typical of baboon pregnancy.[1]


  1. A role for estrogen in progesterone production during baboon pregnancy. Albrecht, E.D. Am. J. Obstet. Gynecol. (1980) [Pubmed]
WikiGenes - Universities