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Chemical Compound Review

MER-25     1-[4-(2- diethylaminoethoxy)phenyl]-2- (4...

Synonyms: CHEMBL47647, SureCN330094, MER 25, NSC-19857, LS-7482, ...
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Disease relevance of ETHAMOXYTRIPHETOL


Psychiatry related information on ETHAMOXYTRIPHETOL

  • The MER-25 did not affect the running of castrated, oil-treated male rats and did not inhibit the running induced by food deprivation [6].

High impact information on ETHAMOXYTRIPHETOL

  • Similarly, administration of the estrogen antagonist MER-25 to intact animals in the last trimester had no effect on maternal serum inhibin concentrations [7].
  • We examined this possibility in the present study by determining the effects of ACTH and estrogen on DHA formation by adrenal cells of fetuses obtained from baboons at mid- and late gestation and from animals administered the antiestrogen MER-25 throughout late gestation [8].
  • Adrenals were removed from baboon fetuses on day 100 (midgestation; n = 7) and day 170 (late gestation; n = 6; term, day 184) of gestation from untreated animals and on day 170 from fetuses whose mothers were treated with MER-25 on days 140-170 (25 mg/kg; n = 7) [8].
  • P-450scc activity, as determined by formation of pregnenolone (P5) and P4 during a 30-min incubation (picomoles per mg protein), was 37% lower (P less than 0.01) in placental mitochondria obtained from MER-25-treated baboons (179.8 +/- 25.0) than in that from untreated (285.4 +/- 13.4) baboons [9].
  • In the present study, increasing amounts of the anti-estrogen 1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenoletha nol (MER-25) were administered to pregnant baboons (Papio anubis) to block the action of endogenous estrogen and to determine effect on placental low-density lipoprotein (LDL) uptake [10].

Chemical compound and disease context of ETHAMOXYTRIPHETOL


Biological context of ETHAMOXYTRIPHETOL


Anatomical context of ETHAMOXYTRIPHETOL


Associations of ETHAMOXYTRIPHETOL with other chemical compounds


Analytical, diagnostic and therapeutic context of ETHAMOXYTRIPHETOL

  • Under each of these endocrine conditions, except after castration alone, the MER-25-treated rats showed a reduced capacity to ejaculate [3].


  1. Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture. Lerner, L.J., Jordan, V.C. Cancer Res. (1990) [Pubmed]
  2. Correlation of anti-inflammatory activity with inhibition of prostaglandin synthesis activity of nonsteroidal anti-estrogens and estrogens (38532). Lerner, E.J., Carminati, P., Schiatti, P. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  3. Effects of anti-oestrogen treatment of neonatal male rats on lordosis behaviour and mounting behaviour in the adult. Södersten, P. J. Endocrinol. (1978) [Pubmed]
  4. A role for estrogen in progesterone production during baboon pregnancy. Albrecht, E.D. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  5. Estrogenic effects of an antiestrogen, MER-25, on eating and body weight in rats. Roy, E.J., Uade, G.N. Journal of comparative and physiological psychology. (1976) [Pubmed]
  6. Role of estrogens in androgen-induced spontaneous activity in male rats. Roy, E.J., Wade, G.N. Journal of comparative and physiological psychology. (1975) [Pubmed]
  7. Regulation of immunoreactive inhibin patterns in baboon pregnancy: maternal, placental, and fetal considerations. Billiar, R.B., Rohan, R., Henson, M.C., Smith, P., Babischkin, J. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  8. Modulation of adrenocorticotropin-stimulated baboon fetal adrenal dehydroepiandrosterone formation in vitro by estrogen at mid- and late gestation. Albrecht, E.D., Henson, M.C., Walker, M.L., Pepe, G.J. Endocrinology (1990) [Pubmed]
  9. Regulation of progesterone biosynthesis by estrogen during baboon pregnancy: placental mitochondrial cholesterol side-chain cleavage activity in antiestrogen (ethamoxytriphetol, MER-25)-treated baboons. Babischkin, J.S., Pepe, G.J., Albrecht, E.D. Endocrinology (1989) [Pubmed]
  10. Regulation of placental low-density lipoprotein uptake in baboons by estrogen: dose-dependent effects of the anti-estrogen ethamoxytriphetol (MER-25). Henson, M.C., Pepe, G.J., Albrecht, E.D. Biol. Reprod. (1991) [Pubmed]
  11. Sexual behaviour of male rats injected with the anti-oestrogen MER-25 during infancy. Booth, J.E. Physiol. Behav. (1977) [Pubmed]
  12. Transuterofetoplacental conversion of pregnenolone to progesterone in antiestrogen-treated baboons. Henson, M.C., Pepe, G.J., Albrecht, E.D. Endocrinology (1987) [Pubmed]
  13. Treatment with different antiestrogens in the neonatal period and effects in the cervicovaginal epithelium and ovaries of adult mice: a comparison to estrogen-induced changes. Forsberg, J.G. Biol. Reprod. (1985) [Pubmed]
  14. Luteal function in baboons with administration of the antiestrogen ethamoxytriphetol (MER-25) throughout the luteal phase of the menstrual cycle. Albrecht, E.D., Haskins, A.L., Hodgen, G.D., Pepe, G.J. Biol. Reprod. (1981) [Pubmed]
  15. Possible mechanisms for the agonist actions of tamoxifen and the antagonist actions of MER-25 (ethamoxytriphetol) in the mouse uterus. Lyman, S.D., Jordan, V.C. Biochem. Pharmacol. (1985) [Pubmed]
  16. Effects of an antioestrogen (MER-25) on sexual and mammary gland morphogenesis of the mouse fetus. Jean-Faucher, C., Berger, M., de Turckheim, M., Veyssière, G., Jean, C. J. Reprod. Fertil. (1977) [Pubmed]
  17. Suprachiasmatic lesions disrupt the daily rhythmicity in the sexual behaviour of normal male rats and of male rats treated neonatally with antioestrogen. Södersten, P., Hansen, S., Srebro, B. J. Endocrinol. (1981) [Pubmed]
  18. Food intake, body weight, and adiposity in female rats: actions and interactions of progestins and antiestrogens. Gray, J.M., Wade, G.N. Am. J. Physiol. (1981) [Pubmed]
  19. Effects of prostaglandins E2 and F2alpha (PGE2; PGF2alpha), trilostane, mifepristone, palmitic acid (PA), indomethacin (INDO), ethamoxytriphetol (MER-25), PGE2 + PA, or PGF2alpha + PA on PGE2, PGF2alpha, and progesterone secretion by bovine corpora lutea of mid-pregnancy in vitro. Weems, Y.S., Lewis, A.W., Randel, R.D., Weems, C.W. The Chinese journal of physiology. (2002) [Pubmed]
  20. Effect of the antiestrogen ethamoxytriphetol (MER-25) and luteectomy on serum progesterone concentrations in pregnant baboons. Albrecht, E.D., Pepe, G.J. Endocrinology (1984) [Pubmed]
  21. The effect of estrogen antagonism on progesterone production in early pregnancy in the baboon (Papio cynocephalus). Castracane, V.D., Kuehl, T.J., Goldzieher, J.W. Am. J. Obstet. Gynecol. (1983) [Pubmed]
  22. Effects of estradiol benzoate and MER-25 on ethanol consumption in the ovariectomized rat. Sandberg, D., Stewart, J. Journal of comparative and physiological psychology. (1982) [Pubmed]
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