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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Multicenter trial of acyclovir and trifluorothymidine in herpetic keratitis.

Acyclovir 3 percent ophthalmic ointment was compared with trifluorothymidine 2 percent ointment in a double-blind trial of 59 herpes keratitis patients. Clinical progress was measured by direct clinical assessment and retrospective photographic evaluation. Ninety percent of acyclovir-treated patients and 75 percent of trifluorothymidine-treated patients had healed within 14 days. There was no significant difference in the rate of healing between the two treatment groups.[1]


  1. Multicenter trial of acyclovir and trifluorothymidine in herpetic keratitis. La Lau, C., Oosterhuis, J.A., Versteeg, J., van Rij, G., Renardel de Lavalette, J.G., Craandijk, A., Lamers, W.R., Mierlobensteyn, T. Am. J. Med. (1982) [Pubmed]
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