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MeSH Review


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Disease relevance of Keratitis


High impact information on Keratitis


Chemical compound and disease context of Keratitis

  • Neurotrophic keratitis was found in 81% of neonatally denervated animals; mortality rate due to HSV-1 infection was reduced from 80% in the controls to 24% in the capsaicin-treated group, and recovery of latent virus by cocultivation was reduced by 50% [11].
  • A combination of acyclovir and dilute steroid drops appeared to be as effective as currently available treatments in the management of disciform keratitis [12].
  • Acyclovir 3 percent ophthalmic ointment was compared with trifluorothymidine 2 percent ointment in a double-blind trial of 59 herpes keratitis patients [13].
  • These studies indicate that cotherapy with ara-A and an adenosine deaminase inhibitor was a reasonable alternative therapy for keratitis due to mutants resistant to therapy with nucleoside analogs which require the virus-specified deoxypyrimidine kinase or DNA polymerase, while ara-A alone was not an effective alternative [14].
  • We therefore conclude that antibody-mediated prevention of stromal keratitis and encephalitis does not require the obligatory participation of CD4+, CD8+, or asialo GM1+ cells [15].

Biological context of Keratitis


Anatomical context of Keratitis


Gene context of Keratitis


Analytical, diagnostic and therapeutic context of Keratitis


  1. Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness). Pearlman, E., Lass, J.H., Bardenstein, D.S., Kopf, M., Hazlett, F.E., Diaconu, E., Kazura, J.W. J. Exp. Med. (1995) [Pubmed]
  2. Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis. Dominguez-Vazquez, A., Taylor, H.R., Greene, B.M., Ruvalcaba-Macias, A.M., Rivas-Alcala, A.R., Murphy, R.P., Beltran-Hernandez, F. Lancet (1983) [Pubmed]
  3. Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. Natt, E., Kida, K., Odievre, M., Di Rocco, M., Scherer, G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Antiviral therapy: current concepts and practices. Bean, B. Clin. Microbiol. Rev. (1992) [Pubmed]
  5. Missense mutations in GJB2 encoding connexin-26 cause the ectodermal dysplasia keratitis-ichthyosis-deafness syndrome. Richard, G., Rouan, F., Willoughby, C.E., Brown, N., Chung, P., Ryynänen, M., Jabs, E.W., Bale, S.J., DiGiovanna, J.J., Uitto, J., Russell, L. Am. J. Hum. Genet. (2002) [Pubmed]
  6. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. Rothenberg, M.E., MacLean, J.A., Pearlman, E., Luster, A.D., Leder, P. J. Exp. Med. (1997) [Pubmed]
  7. Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus. Lee, S., Zheng, M., Kim, B., Rouse, B.T. J. Clin. Invest. (2002) [Pubmed]
  8. Chlorhexidine or polyhexamethylene biguanide for acanthamoeba keratitis. Seal, D.V., Hay, J., Kirkness, C.M. Lancet (1995) [Pubmed]
  9. Keratitis from high doses intravenous cytarabine. Gressel, M.G., Tomsak, R.L. Lancet (1982) [Pubmed]
  10. Current perspectives on ophthalmic mycoses. Thomas, P.A. Clin. Microbiol. Rev. (2003) [Pubmed]
  11. Role of peptidergic neurons in ocular herpes simplex infection in mice. Herbort, C.P., Weissman, S.S., Payan, D.G. FASEB J. (1989) [Pubmed]
  12. Acyclovir in herpes keratitis. Collum, L.M., Logan, P., Hillary, I.B., Ravenscroft, T. Am. J. Med. (1982) [Pubmed]
  13. Multicenter trial of acyclovir and trifluorothymidine in herpetic keratitis. La Lau, C., Oosterhuis, J.A., Versteeg, J., van Rij, G., Renardel de Lavalette, J.G., Craandijk, A., Lamers, W.R., Mierlobensteyn, T. Am. J. Med. (1982) [Pubmed]
  14. Chemotherapy of herpetic keratitis induced by acyclovir-resistant strains of herpes simplex virus type 1. O'Brien, W.J., Taylor, J.L. Am. J. Med. (1982) [Pubmed]
  15. Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells. Staats, H.F., Oakes, J.E., Lausch, R.N. J. Virol. (1991) [Pubmed]
  16. Functional analysis of paired box missense mutations in the PAX6 gene. Tang, H.K., Chao, L.Y., Saunders, G.F. Hum. Mol. Genet. (1997) [Pubmed]
  17. LBP and CD14 secreted in tears by the lacrimal glands modulate the LPS response of corneal epithelial cells. Blais, D.R., Vascotto, S.G., Griffith, M., Altosaar, I. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  18. Histology and immunohistology of Igh-1-restricted herpes simplex keratitis in BALB/c congenic mice. Opremcak, E.M., Rice, B.A., Wells, P.A., Foster, C.S. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  19. Analysis of the herpes simplex virus type 1 UL6 gene in patients with stromal keratitis. Ellison, A.R., Yang, L., Cevallos, A.V., Margolis, T.P. Virology (2003) [Pubmed]
  20. Kinetics of topically administered prednisolone acetate. Optimal concentration for treatment of inflammatory keratitis. Leibowitz, H.M., Kupferman, A. Arch. Ophthalmol. (1976) [Pubmed]
  21. IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. Maertzdorf, J., Osterhaus, A.D., Verjans, G.M. J. Immunol. (2002) [Pubmed]
  22. Experimental onchocercal keratitis. Pearlman, E. Parasitol. Today (Regul. Ed.) (1996) [Pubmed]
  23. Impaired eosinophil recruitment to the cornea in P-selectin-deficient mice in Onchocerca volvulus keratitis (River blindness). Kaifi, J.T., Hall, L.R., Diaz, C., Sypek, J., Diaconu, E., Lass, J.H., Pearlman, E. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  24. Inhibition of corneal inflammation by an acylated superoxide dismutase derivative. Ando, E., Ando, Y., Inoue, M., Morino, Y., Kamata, R., Okamura, R. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  25. Cystic fibrosis transmembrane conductance regulator-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa is a key component in the pathogenesis of experimental murine keratitis. Zaidi, T.S., Lyczak, J., Preston, M., Pier, G.B. Infect. Immun. (1999) [Pubmed]
  26. Mutation of the PAX6 gene in patients with autosomal dominant keratitis. Mirzayans, F., Pearce, W.G., MacDonald, I.M., Walter, M.A. Am. J. Hum. Genet. (1995) [Pubmed]
  27. Leukocyte adhesion molecules in diseased corneas. Philipp, W., Göttinger, W. Invest. Ophthalmol. Vis. Sci. (1993) [Pubmed]
  28. Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10. Tumpey, T.M., Cheng, H., Yan, X.T., Oakes, J.E., Lausch, R.N. J. Leukoc. Biol. (1998) [Pubmed]
  29. Adenovirus keratitis: a role for interleukin-8. Chodosh, J., Astley, R.A., Butler, M.G., Kennedy, R.C. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  30. Acyclovir and vidarabine monophosphate: comparison of iontophoretic and intravenous administration for the treatment of HSV-1 stromal keratitis. Hill, J.M., Kwon, B.S., Burch, K.D., Deback, J., Whang, I., Jones, G.T., Luke, B., Harp, R., Shimomura, Y., Hull, D.S., Gangarosa, L.P. Am. J. Med. (1982) [Pubmed]
  31. Staphylococcus corneal virulence in a new topical model of infection. Hume, E.B., Dajcs, J.J., Moreau, J.M., Sloop, G.D., Willcox, M.D., O'Callaghan, R.J. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  32. Ocular bioerodible minitablets as strategy for the management of microbial keratitis. Weyenberg, W., Vermeire, A., Dhondt, M.M., Adriaens, E., Kestelyn, P., Remon, J.P., Ludwig, A. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
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