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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Induction of hepatic UDP-glucuronyltransferase by oral methaqualone consumption.

Repeated oral administration of methaqualone (100 mg/kg/day) to rats for 6 consecutive days evoked approximately two and a half fold increase in p-nitrophenol glucuronidation by hepatic microsomes. Interestingly, the magnitude of UDP-glucuronyltransferase stimulation by methaqualone, when assessed in crude liver homogenate, was comparable to that obtained with isolated microsomes.[1]


  1. Induction of hepatic UDP-glucuronyltransferase by oral methaqualone consumption. Kaur, S., Ali, B. Res. Commun. Chem. Pathol. Pharmacol. (1982) [Pubmed]
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