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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Origin and production rates of deoxycorticosterone and deoxycorticosterone sulfate in men and nonpregnant women.

In the present investigation, we evaluated the origin of deoxycorticosterone sulfate (DOC-SO4) and the production rates of DOC and DOC-SO4 in men and women. Previously, we found that there was little or no interconverion of plasma DOC and DOC-SO4; this finding was reconfirmed in the present investigation. After the iv infusion of [3H]DOC-SO4 and [14C]DOC, urine was collected for 5 days, DOC-SO4 was isolated and purified as unconjugated DOC, and tetrahydro-DOC glucuronoside was isolated and purified as the unconjugated metabolite. The production rate of DOC in these subjects (mean +/- SEM, 66 +/- 9.8 micrograms/24 h) was computed from the specific activity of urinary [14C]tetrahydro-DOC (glucuronoside); the production rate of DOC-SO4 in these subjects (92 +/- 15.9 micrograms/24 h) was computed from the specific activity of urinary [3H]DOC-SO4. The production rates are expressed on the basis of the molecular weight of DOC. Since plasma DOC and DOC-SO4 are not interconverted, we conclude that both steroids are secretory products, presumably from the adrenal cortex.[1]


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