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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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In vivo induction of granulopoiesis in visceral yolk-sac cells by foetal hepatic factors.

In order to evaluate the hypothetical activity of foetal hepatic factors on putative yolk-sac haemopoietic stem cells we used the Double Diffusion Chamber (DDC) techniqUe. The DDC were made of a regulator compartment, where foetal hepatic tissue was introduced and a test compartment where visceral yolk-sac cells were cultured. In this system a hepatic signal induced the yolk-sac stem cells to differentiate along the granulocytic pathway but did not stimulate yolk-sac CFUs growth. Contrary to CFUs originating from foetal liver or adult bone marrow, yolk-sac CFUs do not increase numerically in diffusion chamber culture.[1]

References

  1. In vivo induction of granulopoiesis in visceral yolk-sac cells by foetal hepatic factors. Anckaert, M.A., Symann, M. Journal of embryology and experimental morphology. (1983) [Pubmed]
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