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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lectin derivatives of methotrexate and chlorambucil as chemotherapeutic agents.

Methotrexate and chlorambucil, each covalently linked to either abrus agglutinin, abrin, ricinus agglutinin, ricin, or concanavalin A, were prepared. A single dose of the derivative injected ip into sarcoma 180-bearing noninbred N:NIH(S) white mice resulted in prolongation of the survival time and was more effective than an equivalent dose of free drug and lectin. Drug-lectin also showed a higher inhibitory effect on the DNA biosynthesis of the tumor cell than did an equivalent dose of the free drug and lectin.[1]


  1. Lectin derivatives of methotrexate and chlorambucil as chemotherapeutic agents. Lin, J.Y., Li, J.S., Tung, T.C. J. Natl. Cancer Inst. (1981) [Pubmed]
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