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Disease relevance of Ricinus


High impact information on Ricinus

  • The localization of fluorescein-labeled lectins, i.e., concanavalin A (Con A), Ricinus communis-120 (RCA), and wheat-germ agglutinin (WGA), were studied histologically in F344 rat epithelial lesions produced in the course of chemical carcinogenesis [6].
  • Binding of 125I-FVIII/vWF to platelets can be competitively inhibited by unlabeled human or bovine FVIII/vWF, but not by human thrombin, fibrinogen, alpha 2-macroglobulin, equine collagen, or a lectin of Ricinus communis [7].
  • Tubulovesicles were heavily stained by wheat germ, Helix pomatia, and Ricinus communis I lectins, indicative of N-acetylhexosamine- and galactose-containing glycoconjugates [8].
  • After proximal resection or transposition of intestinal segments, the small intestinal mucosa of rats was examined with fluorescein-conjugated lectins derived from Ricinus communis and Triticum vulgare (wheat germ) [9].
  • The binding of HPA was weakly inhibited by a beta-D-galactose-reactive lectin isolated from Ricinus communis (designated RCA1) [10].

Chemical compound and disease context of Ricinus

  • Ecchordosis physaliphora and eight chordomas were stained with Ricinus communis type I, Canavalia ensiformis, Triticum vulgaris, and Limax flavus [11].
  • To determine the location of some sulfate esters on respiratory mucins, an unambiguous sequencing strategy was developed for a crude, monosulfated oligosaccharide fraction derived from tracheobronchial mucous glycoproteins, isolated from sputum from a patient with cystic fibrosis, and which possessed Ricinus communis-I lectin affinity [12].
  • During natural exposure on grazing heavily infested with Ixodes ricinus, seven out of 42 cattle with no previous exposure to tick-borne diseases were injected every four days with a long acting preparation of oxytetracycline at a dose rate of 20 mg/kg [13].
  • The effects of testosterone on acquired resistance to ticks, Ixodes ricinus, in their natural rodent hosts (voles, Clethrionomys glareolus, and wood-mice, Apodemus sylvaticus) were investigated by manipulating testosterone levels and exposing the hosts to repeated tick infestations [14].
  • However, the molecules exclusively reacting with anti-HMFG III D 5, a monoclonal antibody previously shown to detect antigen(s) positively correlating with the expression of estrogen receptors in mammary and gynaecological carcinomas, could only be stained with peanut agglutinin and Ricinus communis-lectins [15].

Biological context of Ricinus

  • To unravel the structure of PLD and further the investigation of its modes of regulation and cellular function, we have isolated a PLD cDNA from castor bean (Ricinus communis L. var. Hale) by using oligonucleotide probes based on the N-terminal amino acid sequence of purified PLD protein [16].
  • The antibody specificity indicates that structural differences exist in the galactose-binding sites of the Ricinus communis lectins [17].
  • Comparison of residues at position 148 of FAD2, LFAH, and the Ricinus oleate hydroxylase prompted us to rationally engineer LFAH-N149I, a variant with approximately 1.9-fold increase in hydroxylation specificity compared with that of wild-type LFAH [18].
  • Plasmid omega-3 fatty acid desaturase cDNA from Ricinus communis [19].
  • Female mouse recipients of male bone marrow grafts showed co-localization of Y-chromosomes and tubular epithelial markers Ricinus communis and Lens culinaris, and a specific cytochrome P450 enzyme (CYP1A2) indicating an appropriate functional capability of clustered newly formed marrow-derived tubular epithelial cells [20].

Anatomical context of Ricinus

  • This lectin, along with wheat germ, soybean, Helix pomatia, and Ricinus communis I lectins, bound to oxyntic cell basolateral membranes, indicating mannose, N-acetylhexosamine, and galactose residues [8].
  • Labeling of aldehyde-prefixed cultures with wheat-germ agglutinin or with the galactose-specific lectin of Ricinus communis is consistently dense near the distal end of the neurites [21].
  • Two different lectin--glycolipid combinations [Ricinus communis agglutinin I-lactosylcerebroside and concanavalin A-tetradecyl- (or hexadecyl-) maltobionamide] were used to promote attachment of lipid vesicles before polyethylene glycol-induced fusion with BG-9 human fibroblasts, NIL-8M2 hamster cells, or L-929 mouse cells [22].
  • Injection of (rhodamine-labeled) Ricinus communis I lectin showed focal spots of exposed basement membrane in the alveolar capillaries and in some larger pulmonary vessels [23].
  • By contrast, lectins that require exposed non-reducing galactose residues for binding (Ricinus communis agglutinin1 and Bauhinia purpurea agglutinin) preferentially labeled the mucin of less-differentiated goblet cells located in the lower portion of the colonic crypt [24].

Associations of Ricinus with chemical compounds

  • These intracellular capsid-binding membranes (ICBMs) were not stained by cytochemical markers for endoplasmic reticulum (ER) (glucose-6-phosphatase) or trans Golgi cisternae (thiamine pyrophosphatase, acid phosphatase) but were labeled by Ricinus communis agglutinin I (RCA) in thin, frozen sections [25].
  • An oleate 12-hydroxylase from Ricinus communis L. is a fatty acyl desaturase homolog [26].
  • The lectin of another slime mold, Polysphondylium pallidum (pallidin) and the lectin of Ricinus communis (RCA-I) were also more potent agglutinins of fixed differentiated D. discoideum cells than of fixed vegetative D. discoideum cells [27].
  • Chromatography of glycopeptides on concanavalin A-Sepharose, Ricinus communis agglutinin I-agarose, and Bio-Gel P-4 columns excluded a higher degree of branching but suggested addition of extra terminal sialic acid residues as the major cause of the observed alterations [28].
  • The molecule isolated by immunoaffinity from HOON is a glycoprotein since it bound to Ricinus communis agglutinin, wheat germ agglutinin, and peanut agglutinin lectins [29].

Gene context of Ricinus

  • Most of the asymmetric and G(A)4 AChE species were bound to Triticum vulgaris (WGA) or Ricinus communis (RCA) agglutinins [30].
  • All together, these results indicate that I. ricinus nymphal ticks antigens are able to elicit expression of IFN-gamma, IL-2 mRNA and to a lesser extent IL-4 mRNA in both skin and draining lymph nodes [31].
  • Most of the AChE in brain and CSF was associated to concanavalin A (Con A), Lens culinaris (LCA) and Triticum vulgaris (WGA) agglutinins, but little activity was adsorbed to Ricinus communis agglutinin I (RCAI) [32].
  • Infiltration of CD4+ CD8+ T cells, and expression of ICAM-1, Ia antigens, IL-1 alpha and TNF-alpha in the skin lesion of BALB/c mice undergoing repeated infestations with nymphal Ixodes ricinus ticks [33].
  • However, Ricinus communis agglutinin-I lectin blot analysis revealed that the enhanced beta1,4-GT1 activity did not increase the Galbetal-->4GlcNAc groups on most of the membrane proteins in p58GTA/7721 cells [34].

Analytical, diagnostic and therapeutic context of Ricinus


  1. Cancer gene therapy by thyroid hormone-mediated expression of toxin genes. Martín, V., Cortés, M.L., de Felipe, P., Farsetti, A., Calcaterra, N.B., Izquierdo, M. Cancer Res. (2000) [Pubmed]
  2. Secretion of Ricinus communis glyceraldehyde-3-phosphate dehydrogenase by Escherichia coli. Hekman, W.E., Dennis, D.T., Miernyk, J.A. Mol. Microbiol. (1990) [Pubmed]
  3. Heterogeneity of sugar composition of factor VIII/von Willebrand factor in von Willebrand's disease: analysis by crossed affinoimmunoelectrophoresis using lectin (ricinus communis agglutinin-120). Mikami, S., Ueda, M., Yasui, M., Takahashi, Y., Nishino, M., Fukui, H. Thromb. Haemost. (1983) [Pubmed]
  4. Histochemical and biochemical aspects of lectin binding glycoproteins in primary and metastatic adenocarcinoma in the lung. Kawai, T., Suzuki, M. Mod. Pathol. (1994) [Pubmed]
  5. Isolation of atherogenic modified (desialylated) low density lipoprotein from blood of atherosclerotic patients: separation from native lipoprotein by affinity chromatography. Tertov, V.V., Sobenin, I.A., Tonevitsky, A.G., Orekhov, A.N., Smirnov, V.N. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  6. Lectin-binding sites in preneoplastic and neoplastic lesions of human and rodent respiratory tracts. Shiba, M., Ohiwa, T., Klein-Szanto, A.J. J. Natl. Cancer Inst. (1984) [Pubmed]
  7. Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets. Kao, K.J., Pizzo, S.V., McKee, P.A. J. Clin. Invest. (1979) [Pubmed]
  8. Distribution of lectin-binding sites in oxyntic and chief cells of isolated rabbit gastric glands. Okamoto, C.T., Forte, J.G. Gastroenterology (1988) [Pubmed]
  9. Alterations in cell surface membrane components of adapting rat small intestinal epithelium. Studies with lectins after massive proximal jejunoileal resection and jejunoileal transposition. Freeman, H.J., Etzler, M.E., Garrido, A.B., Kim, Y.S. Gastroenterology (1978) [Pubmed]
  10. Interaction of lectins with membrane receptors on erythrocyte surfaces. Sung, L.A., Kabat, E.A., Chien, S. J. Cell Biol. (1985) [Pubmed]
  11. Lectin histochemistry of human fetal notochord, ecchordosis physaliphora, and chordomas. Kaneko, Y., Iwaki, T., Fukui, M. Arch. Pathol. Lab. Med. (1992) [Pubmed]
  12. Structural analysis of monosulfated side-chain oligosaccharides isolated from human tracheobronchial mucous glycoproteins. Mawhinney, T.P., Adelstein, E., Gayer, D.A., Landrum, D.C., Barbero, G.J. Carbohydr. Res. (1992) [Pubmed]
  13. Inhibition of Babesia divergens in cattle by oxytetracycline. Taylor, S.M., Elliott, C.T., Kenny, J. Vet. Rec. (1986) [Pubmed]
  14. Testosterone depresses innate and acquired resistance to ticks in natural rodent hosts: a force for aggregated distributions of parasites. Hughes, V.L., Randolph, S.E. J. Parasitol. (2001) [Pubmed]
  15. Lectin binding affinities of human milk fat globule (HMFG) membrane antigens. Ashorn, P., Vilja, P., Ashorn, R., Krohn, K. Mol. Immunol. (1986) [Pubmed]
  16. Cloning and expression of phosphatidylcholine-hydrolyzing phospholipase D from Ricinus communis L. Wang, X., Xu, L., Zheng, L. J. Biol. Chem. (1994) [Pubmed]
  17. Identification and characterization of a monoclonal antibody recognizing a galactose-binding domain of the toxin ricin. Colombatti, M., Johnson, V.G., Skopicki, H.A., Fendley, B., Lewis, M.S., Youle, R.J. J. Immunol. (1987) [Pubmed]
  18. Desaturation and hydroxylation. Residues 148 and 324 of Arabidopsis FAD2, in addition to substrate chain length, exert a major influence in partitioning of catalytic specificity. Broadwater, J.A., Whittle, E., Shanklin, J. J. Biol. Chem. (2002) [Pubmed]
  19. Plasmid omega-3 fatty acid desaturase cDNA from Ricinus communis. van de Loo, F.J., Somerville, C. Plant Physiol. (1994) [Pubmed]
  20. Bone marrow contributes to renal parenchymal turnover and regeneration. Poulsom, R., Forbes, S.J., Hodivala-Dilke, K., Ryan, E., Wyles, S., Navaratnarasah, S., Jeffery, R., Hunt, T., Alison, M., Cook, T., Pusey, C., Wright, N.A. J. Pathol. (2001) [Pubmed]
  21. Lectin labeling of sprouting neurons. II. Relative movement and appearance of glycoconjugates during plasmalemmal expansion. Pfenninger, K.H., Maylié-Pfenninger, M.F. J. Cell Biol. (1981) [Pubmed]
  22. Use of lectins and polyethylene glycol for fusion of glycolipid-containing liposomes with eukaryotic cells. Szoka, F., Magnusson, K.E., Wojcieszyn, J., Hou, Y., Derzko, Z., Jacobson, K. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  23. Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Corada, M., Mariotti, M., Thurston, G., Smith, K., Kunkel, R., Brockhaus, M., Lampugnani, M.G., Martin-Padura, I., Stoppacciaro, A., Ruco, L., McDonald, D.M., Ward, P.A., Dejana, E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  24. Alterations in human colonic mucin occurring with cellular differentiation and malignant transformation. Boland, C.R., Montgomery, C.K., Kim, Y.S. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  25. Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. Griffiths, G., Quinn, P., Warren, G. J. Cell Biol. (1983) [Pubmed]
  26. An oleate 12-hydroxylase from Ricinus communis L. is a fatty acyl desaturase homolog. van de Loo, F.J., Broun, P., Turner, S., Somerville, C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  27. Cell surface species-specific high affinity receptors for discoidin: developmental regulation in Dictyostelium discoideum. Reitherman, R.W., Rosen, S.D., Frasier, W.A., Barondes, S.H. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  28. Modification of cell surface carbohydrates and invasive behavior by an alkyl lysophospholipid. Bolscher, J.G., Schallier, D.C., van Rooy, H., Storme, G.A., Smets, L.A. Cancer Res. (1988) [Pubmed]
  29. Biochemical characterization of the 44G4 antigen from the HOON pre-B leukemic cell line. Gougos, A., Letarte, M. J. Immunol. (1988) [Pubmed]
  30. Characterization of acetylcholinesterase and butyrylcholinesterase forms in normal and dystrophic Lama2dy mouse heart. Gómez, J.L., Moral-Naranjo, M.T., Campoy, F.J., Vidal, C.J. J. Neurosci. Res. (1999) [Pubmed]
  31. IFN-gamma IL-2, and IL-4 mRNA expression in the skin and draining lymph nodes of BALB/c mice repeatedly infested with nymphal Ixodes ricinus ticks. Mbow, M.L., Rutti, B., Brossard, M. Cell. Immunol. (1994) [Pubmed]
  32. Ricinus communis agglutinin I reacting and non-reacting butyrylcholinesterase in human cerebrospinal fluid. Tornel, P.L., Sáez-Valero, J., Vidal, C.J. Neurosci. Lett. (1992) [Pubmed]
  33. Infiltration of CD4+ CD8+ T cells, and expression of ICAM-1, Ia antigens, IL-1 alpha and TNF-alpha in the skin lesion of BALB/c mice undergoing repeated infestations with nymphal Ixodes ricinus ticks. Mbow, M.L., Rutti, B., Brossard, M. Immunology (1994) [Pubmed]
  34. Effect of p58GTA on beta-1,4-galactosyltransferase 1 activity and cell-cycle in human hepatocarcinoma cells. Zhang, S.W., Xu, S.L., Cai, M.M., Yan, J., Zhu, X.Y., Hu, Y., Gu, J.X. Mol. Cell. Biochem. (2001) [Pubmed]
  35. Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis. Bagasra, O., Michaels, F.H., Zheng, Y.M., Bobroski, L.E., Spitsin, S.V., Fu, Z.F., Tawadros, R., Koprowski, H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  36. Lectin affinity high-performance liquid chromatography. Interactions of N-glycanase-released oligosaccharides with Ricinus communis agglutinin I and Ricinus communis agglutinin II. Green, E.D., Brodbeck, R.M., Baenziger, J.U. J. Biol. Chem. (1987) [Pubmed]
  37. Olfactomedin: purification, characterization, and localization of a novel olfactory glycoprotein. Snyder, D.A., Rivers, A.M., Yokoe, H., Menco, B.P., Anholt, R.R. Biochemistry (1991) [Pubmed]
  38. Fluorescence-polarization studies on binding of 4-methylumbelliferyl beta-D-galactopyranoside to Ricinus communis (castor-bean) agglutinin. Khan, M.I., Mathew, M.K., Balaram, P., Surolia, A. Biochem. J. (1980) [Pubmed]
  39. A cysteine endopeptidase with a C-terminal KDEL motif isolated from castor bean endosperm is a marker enzyme for the ricinosome, a putative lytic compartment. Schmid, M., Simpson, D., Kalousek, F., Gietl, C. Planta (1998) [Pubmed]
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