The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Activation of membrane-bound kallikrein and renin in the kidney.

Rat kidney contains membrane-bound renin (EC and kallikrein (EC Kallikrein activity was measured by a spectrophotometric assay and renin by radioimmunoassay. Plasma membrane-bound kallikrein was activated by lysolecithin and by melittin, which was a more potent activator., This activation by mellitin was independent of calcium concentration. Mellitin was, however, a more potent activator of membrane-bound renin in the presence of calcium. Administration of aldosterone to rats for 6 days increased kallikrein activity in the renal homogenate and in the membrane-enriched fractions, whereas renin activity was not affected. It was proposed that kallikrein may also be located on the basal membrane of tubular epithelial cells, where aldosterone can enhance its activity.[1]


  1. Activation of membrane-bound kallikrein and renin in the kidney. Nishimura, K., Alhenc-Gelas, F., White, A., Erdös, E.G. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
WikiGenes - Universities