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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Deleterious effect of prednisolone in HBsAg-positive chronic active hepatitis.

To study the efficacy of corticosteroids in chronic active hepatitis (CAH) positive for hepatitis B surface antigen (HBsAg), we pair-randomized 51 patients to receive either 15 to 20 mg of prednisolone per day or a placebo. After initial remission, the maintenance dosage of prednisolone was 10 mg per day, and the patients were prospectively followed for up to 3 1/2 years. Prednisolone decreased serum bilirubin (P < 0.05) and globulin (P < 0.01) at three months; it delayed other biochemical remission occurring after the second month of medication (P < 0.001); it hastened biochemical relapse (P < 0.0001); and it increased the frequency of complications (P < 0.0001) and the death rate (P < 0.01). We conclude that prednisolone has an overall harmful effect in patients with HBsAg-positive CAH.[1]


  1. Deleterious effect of prednisolone in HBsAg-positive chronic active hepatitis. Lam, K.C., Lai, C.L., Trepo, C., Wu, P.C. N. Engl. J. Med. (1981) [Pubmed]
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