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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Specific antibodies to theophylline for use in a homogeneous enzyme immunoassay.

Bovine serum albumin conjugate of 1-methyl-3-(3'-carboxypropyl)xanthine elicits highly specific anti-theophylline antibodies when injected into sheep. When used in a homogeneous enzyme immunoassay for theophylline these antibodies show insignificant cross-reactivity (less than 1%) to 1-methyl- and 1,3-dimethyluric acid, 3-methylxanthine, caffeine, and theobromine. In contrast, immunogens prepared from the C-8 functionalized drug afford antibodies which show more serious cross-reactivity to these compounds. Plausible rationale for attachment of the drug to carrier proteins through its N-3 position which furnished specific antibodies are given.[1]


  1. Specific antibodies to theophylline for use in a homogeneous enzyme immunoassay. Singh, P., Hu, M.W., Gushaw, J.B., Ullman, E.F. Journal of immunoassay. (1980) [Pubmed]
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