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Chemical Compound Review

CHEMBL795     1,3-dimethyl-7,9- dihydropurine-2,6,8-trione

Synonyms: SureCN438597, AG-K-80643, AG-L-62910, SureCN3194191, CHEBI:68447, ...
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Disease relevance of Ba 2751


High impact information on Ba 2751


Chemical compound and disease context of Ba 2751


Biological context of Ba 2751

  • In the ST-pretreated group, plasma concentration (Cp), the area under Cp-time profile (AUC) and urinary excretion of TP increased significantly, and urinary excretion of TP metabolites, 1,3-dimethyluric acid (DMU) and 1-methyluric acid (1MU) decreased significantly [10].

Anatomical context of Ba 2751


Associations of Ba 2751 with other chemical compounds


Gene context of Ba 2751


Analytical, diagnostic and therapeutic context of Ba 2751


  1. Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine. Orlando, R., Padrini, R., Perazzi, M., De Martin, S., Piccoli, P., Palatini, P. Clin. Pharmacol. Ther. (2006) [Pubmed]
  2. Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation. Yu, S.Y., Chung, H.C., Kim, E.J., Kim, S.H., Lee, I., Kim, S.G., Lee, M.G. J. Pharm. Pharmacol. (2002) [Pubmed]
  3. Pharmacokinetics of theophylline in diabetes mellitus rats: induction of CYP1A2 and CYP2E1 on 1,3-dimethyluric acid formation. Kim, Y.C., Lee, A.K., Lee, J.H., Lee, I., Lee, D.C., Kim, S.H., Kim, S.G., Lee, M.G. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2005) [Pubmed]
  4. Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m). Streit, M., Göggelmann, C., Dehnert, C., Burhenne, J., Riedel, K.D., Menold, E., Mikus, G., Bärtsch, P., Haefeli, W.E. Eur. J. Clin. Pharmacol. (2005) [Pubmed]
  5. Neonatal theophylline intoxication: pharmacokinetics and clinical evaluation. Skopnik, H., Bergt, U., Heimann, G. Eur. J. Pediatr. (1992) [Pubmed]
  6. Theophylline metabolism in premature infants. Tserng, K.Y., King, K.C., Takieddine, F.N. Clin. Pharmacol. Ther. (1981) [Pubmed]
  7. Increase in apparent theophylline concentration in the serum of two patients as measured by some immunoassay methods (caused by 1,3-dimethyluric acid?). Opheim, K.E., Ainardi, V., Raisys, V.A. Clin. Chem. (1983) [Pubmed]
  8. Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver. El-Kadi, A.O., Maurice, H., Ong, H., du Souich, P. Br. J. Pharmacol. (1997) [Pubmed]
  9. Lack of effect of highly purified subunit influenza vaccination on theophylline metabolism. Winstanley, P.A., Tjia, J., Back, D.J., Hobson, D., Breckenridge, A.M. British journal of clinical pharmacology. (1985) [Pubmed]
  10. Inhibition of theophylline metabolism by suplatast and its metabolites in rats. Kizawa, M., Miyamoto, E., Aono, S., Kawakami, J., Adachi, I. Biol. Pharm. Bull. (2005) [Pubmed]
  11. Biotransformation of theophylline in cirrhotic rats induced by biliary obstruction. Park, E.J., Ko, G., Kim, J., Sohn, D.H. Arch. Pharm. Res. (1999) [Pubmed]
  12. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: potent inhibition by fluvoxamine. Rasmussen, B.B., Maënpää, J., Pelkonen, O., Loft, S., Poulsen, H.E., Lykkesfeldt, J., Brøsen, K. British journal of clinical pharmacology. (1995) [Pubmed]
  13. Effect of a newly developed ketolide antibiotic, telithromycin, on metabolism of theophylline and expression of cytochrome P450 in rats. Nosaka, H., Nadai, M., Kato, M., Yasui, K., Yoshizumi, H., Miyoshi, M., Zhao, Y.L., Baba, K., Takagi, K., Hasegawa, T. Life Sci. (2006) [Pubmed]
  14. Effect of xanthine-related compounds on a theophylline assay using theophylline oxidase. Vaughan, L.M., Gottehrer, A. The Annals of pharmacotherapy. (1992) [Pubmed]
  15. Specific antibodies to theophylline for use in a homogeneous enzyme immunoassay. Singh, P., Hu, M.W., Gushaw, J.B., Ullman, E.F. Journal of immunoassay. (1980) [Pubmed]
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