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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Liver membrane antibodies in alcoholic liver disease: 1. prevalence and immunoglobulin class.

Using an indirect immunofluorescence technique liver membrane antibodies of IgG and IgA class have been demonstrated in a statistically significant proportion of sera from patients with alcoholic hepatitis and alcoholic cirrhosis. IgG and IgA class antibodies were found respectively in 23 and 25% of 48 patients with alcoholic hepatitis, in 27 and 33% of 84 with active cirrhosis, and 67 and 58% of 12 with inactive cirrhosis. These results provide evidence of a humoral immune response in alcoholic liver disease which is directed against, as yet undefined, liver-cell membrane antigens.[1]

References

  1. Liver membrane antibodies in alcoholic liver disease: 1. prevalence and immunoglobulin class. Burt, A.D., Anthony, R.S., Hislop, W.S., Bouchier, I.A., MacSween, R.N. Gut (1982) [Pubmed]
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