The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Hepatitis, Alcoholic

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hepatitis, Alcoholic


Psychiatry related information on Hepatitis, Alcoholic


High impact information on Hepatitis, Alcoholic


Chemical compound and disease context of Hepatitis, Alcoholic


Biological context of Hepatitis, Alcoholic


Anatomical context of Hepatitis, Alcoholic

  • These results suggest that a major part of the proteinous chemotactic factors released from hepatocytes exposed to ethanol could be a dimer form of interleukin-8, one of the proinflammatory cytokines, possibly contributing to the pathogenesis of alcoholic hepatitis [22].
  • After lipopolysaccharide stimulation, mean monocyte tumor necrosis factor release from alcoholic hepatitis patients was significantly increased to over twice that of healthy controls (25.3 +/- 3.7 vs. 10.9 +/- 2.4 units per ml, p less than 0.005) [23].
  • As expected, normal livers showed CYP2E1 immunostaining confined to a rim, two to three cells thick, around terminal hepatic venule, while livers from alcoholic hepatitis patients showed increased CYP2E1 staining [24].
  • The ICAM-1/LFA-1 pathway may therefore be involved in leukocyte mediated tissue damage during alcoholic hepatitis [25].
  • CONCLUSION: Severe alcoholic hepatitis appears to be associated with polymorphonuclear neutrophil activation and an imbalance between pro- and anti-inflammatory cytokines; during steroid therapy a normalization of these parameters was observed [26].

Gene context of Hepatitis, Alcoholic


Analytical, diagnostic and therapeutic context of Hepatitis, Alcoholic


  1. Homozygosity for alanine in the mitochondrial targeting sequence of superoxide dismutase and risk for severe alcoholic liver disease. Degoul, F., Sutton, A., Mansouri, A., Cepanec, C., Degott, C., Fromenty, B., Beaugrand, M., Valla, D., Pessayre, D. Gastroenterology (2001) [Pubmed]
  2. Double-blind, controlled trial of propylthiouracil in patients with severe acute alcoholic hepatitis. Hallé, P., Paré, P., Kaptein, E., Kanel, G., Redeker, A.G., Reynolds, T.B. Gastroenterology (1982) [Pubmed]
  3. Diazepam and paraldehyde for treatment of severe delirium tremens. A controlled trial. Thompson, W.L., Johnson, A.D., Maddrey, W.L. Ann. Intern. Med. (1975) [Pubmed]
  4. Predictive value of whole blood chemiluminescence in patients with alcoholic hepatitis. Lunel, F., Descamps-Latscha, B., Descamps, D., Le Charpentier, Y., Grippon, P., Valla, D., Cadranel, J.F., Trum, J., Opolon, P. Hepatology (1990) [Pubmed]
  5. Antibodies against acetaldehyde-modified protein epitopes in human alcoholics. Niemelä, O., Klajner, F., Orrego, H., Vidins, E., Blendis, L., Israel, Y. Hepatology (1987) [Pubmed]
  6. Ethanol-induced increase in cytosolic estrogen receptors in human male liver: a possible explanation for biochemical feminization in chronic liver disease due to alcohol. Villa, E., Baldini, G.M., Rossini, G.P., Pasquinelli, C., Melegari, M., Cariani, E., Tata, C., Bellentani, S., Ferrari, A., Manenti, F. Hepatology (1988) [Pubmed]
  7. Relative versus absolute carbohydrate-deficient transferrin as a marker of alcohol consumption in patients with acute alcoholic hepatitis. Halm, U., Tannapfel, A., Mössner, J., Berr, F. Alcohol. Clin. Exp. Res. (1999) [Pubmed]
  8. Prednisolone in severe alcoholic hepatitis. Morgan, T.R. N. Engl. J. Med. (1992) [Pubmed]
  9. Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. Mendenhall, C.L., Anderson, S., Garcia-Pont, P., Goldberg, S., Kiernan, T., Seeff, L.B., Sorrell, M., Tamburro, C., Weesner, R., Zetterman, R. N. Engl. J. Med. (1984) [Pubmed]
  10. Localization of T and B cells and alpha fetoprotein in hepatic biopsies from patients with liver disease. Husby, G., Strickland, R.G., Caldwell, J.L., Williams, R.C. J. Clin. Invest. (1975) [Pubmed]
  11. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Akriviadis, E., Botla, R., Briggs, W., Han, S., Reynolds, T., Shakil, O. Gastroenterology (2000) [Pubmed]
  12. Propylthiouracil for alcoholic hepatitis: potential role of the ethanol metabolic rate. Szilagyi, A. Gastroenterology (1982) [Pubmed]
  13. Propylthiouracil treatment for alcoholic hepatitis: should it and does it work? Kaplowitz, N. Gastroenterology (1982) [Pubmed]
  14. Failure of colchicine to improve short-term survival in patients with alcoholic hepatitis. Akriviadis, E.A., Steindel, H., Pinto, P.C., Fong, T.L., Kanel, G., Reynolds, T.B., Gupta, S. Gastroenterology (1990) [Pubmed]
  15. Tumor necrosis factor in alcoholic hepatitis. Sweeting, J. Gastroenterology (1989) [Pubmed]
  16. Immunoglobulin A antibody to a 200-kilodalton cytosolic acetaldehyde adduct in alcoholic hepatitis. Koskinas, J., Kenna, J.G., Bird, G.L., Alexander, G.J., Williams, R. Gastroenterology (1992) [Pubmed]
  17. Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis. Theodossi, A., Eddleston, A.L., Williams, R. Gut (1982) [Pubmed]
  18. Increased ethane exhalation, an in vivo index of lipid peroxidation, in alcohol-abusers. Lettéron, P., Duchatelle, V., Berson, A., Fromenty, B., Fisch, C., Degott, C., Benhamou, J.P., Pessayre, D. Gut (1993) [Pubmed]
  19. Increased nuclear tri-iodothyronine binding and thyroid hormone-stimulated glucose consumption in mononuclear blood cells from patients with liver cirrhosis. Kvetny, J., Matzen, L. J. Endocrinol. (1991) [Pubmed]
  20. Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Lee, T.D., Sadda, M.R., Mendler, M.H., Bottiglieri, T., Kanel, G., Mato, J.M., Lu, S.C. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
  21. Alpha-1-antitrypsin Pi S phenotype and liver cell inclusion bodies in alcoholic hepatitis. Kelly, J.K., Taylor, T.V., Milford-Ward, A. J. Clin. Pathol. (1979) [Pubmed]
  22. Production of chemotactic factor, interleukin-8, from hepatocytes exposed to ethanol. Shiratori, Y., Takada, H., Hikiba, Y., Nakata, R., Okano, K., Komatsu, Y., Niwa, Y., Matsumura, M., Shiina, S., Omata, M. Hepatology (1993) [Pubmed]
  23. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. McClain, C.J., Cohen, D.A. Hepatology (1989) [Pubmed]
  24. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Weltman, M.D., Farrell, G.C., Hall, P., Ingelman-Sundberg, M., Liddle, C. Hepatology (1998) [Pubmed]
  25. Is the intercellular adhesion molecule-1/leukocyte function associated antigen 1 pathway of leukocyte adhesion involved in the tissue damage of alcoholic hepatitis? Burra, P., Hubscher, S.G., Shaw, J., Elias, E., Adams, D.H. Gut (1992) [Pubmed]
  26. Blood neutrophil functions and cytokine release in severe alcoholic hepatitis: effect of corticosteroids. Taïeb, J., Mathurin, P., Elbim, C., Cluzel, P., Arce-Vicioso, M., Bernard, B., Opolon, P., Gougerot-Pocidalo, M.A., Poynard, T., Chollet-Martin, S. J. Hepatol. (2000) [Pubmed]
  27. Chemokine levels in human liver homogenates: associations between GRO alpha and histopathological evidence of alcoholic hepatitis. Maltby, J., Wright, S., Bird, G., Sheron, N. Hepatology (1996) [Pubmed]
  28. Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease. Fisher, N.C., Neil, D.A., Williams, A., Adams, D.H. Gut (1999) [Pubmed]
  29. A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis. Menon, K.V., Stadheim, L., Kamath, P.S., Wiesner, R.H., Gores, G.J., Peine, C.J., Shah, V. Am. J. Gastroenterol. (2004) [Pubmed]
  30. Decreased activity of plasma ADAMTS13 may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis. Uemura, M., Matsuyama, T., Ishikawa, M., Fujimoto, M., Kojima, H., Sakurai, S., Ishii, S., Toyohara, M., Yamazaki, M., Yoshiji, H., Yamao, J., Matsumoto, M., Ishizashi, H., Fujimura, Y., Fukui, H. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  31. Balance between pro and anti-inflammatory cytokines in patients with acute alcoholic hepatitis. Naveau, S., Balian, A., Capron, F., Raynard, B., Fallik, D., Agostini, H., Grangeot-Keros, L., Portier, A., Galanaud, P., Chaput, J.C., Emilie, D. Gastroenterol. Clin. Biol. (2005) [Pubmed]
  32. Elevation of chemotactic factor inactivator in alcoholic liver disease. Robbins, R.A., Zetterman, R.K., Kendall, T.J., Gossman, G.L., Monsour, H.P., Rennard, S.I. Hepatology (1987) [Pubmed]
  33. The Mallory body: morphological, clinical and experimental studies (Part 1 of a literature survey). Jensen, K., Gluud, C. Hepatology (1994) [Pubmed]
  34. A prospective multicenter study of insulin and glucagon infusion therapy in acute alcoholic hepatitis. Fehér, J., Cornides, A., Romány, A., Kárteszi, M., Szalay, L., Gógl, A., Picazo, J. J. Hepatol. (1987) [Pubmed]
  35. Liver function in patients with mild alcoholic hepatitis, after enflurane, nitrous oxide-narcotic, and spinal anesthesia. Zinn, S.E., Fairley, H.B., Glenn, J.D. Anesth. Analg. (1985) [Pubmed]
  36. Lack of plasma complement activation in severe acute alcoholic hepatitis. Bird, G.L., Lau, J.Y., Davies, E.T., Williams, R.S. Alcohol. Clin. Exp. Res. (1995) [Pubmed]
WikiGenes - Universities