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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of 16,16-dimethyl prostaglandin-E2 given intra-arterially or intra-gastrically, on acid secretion by canine stomachs perfused ex vivo.

Isolated whole canine stomachs, perfused ex vivo with homologous blood, were used for studying the effect of 16,16-dimethyl prostaglandin-E2 (dmPGE2) on gastric secretion. DmPGE2 was administered either into the gastric artery or instilled intragastrically through an esophageal cannula. Histamine, infused intra-arterially, induced acid secretion of all ex vivo stomachs and this was significantly inhibited by intra-arterially or intra-gastrically administered dmPGE2: volume of secretion, output of HCl and concentration of H+ were decreased and gastric peripheral vascular resistance was significantly reduced. The inhibitory action of dmPGE2 continued after its administration was stopped.[1]

References

  1. Effect of 16,16-dimethyl prostaglandin-E2 given intra-arterially or intra-gastrically, on acid secretion by canine stomachs perfused ex vivo. Kowalewski, K., Kolodej, A. Prostaglandins (1978) [Pubmed]
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