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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The relationship between episodic variations of plasma prolactin and REM-non-REM cyclicity is an artifact.

The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.[1]

References

  1. The relationship between episodic variations of plasma prolactin and REM-non-REM cyclicity is an artifact. Van Cauter, E., Desir, D., Refetoff, S., Spire, J.P., Neol, P., H'Hermite, M., Robyn, C., Copinschi, G. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
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