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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Prazosin in the diagnosis and treatment of pheochromocytoma.

In a patient with paraganglioma, severe hypertension due to high levels of plasma norepinephrine was easily controlled with prazosin hydrochloride, 6 to 8 mg/day for 19 days before surgery. A prolonged antihypertensive response to the first two 1-mg doses suggested the presence of pheochromocytoma. This experience dramatizes the remarkable effectiveness of prazosin as a postsynaptic alpha-adrenergic receptor blocker and invites further trials of the drug for both the diagnosis and treatment of pheochromocytoma.[1]


  1. Prazosin in the diagnosis and treatment of pheochromocytoma. Wallace, J.M., Gill, D.P. JAMA (1978) [Pubmed]
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