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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Developmental changes in glucose transport of guinea pig erythrocytes.

The developmental changes in the capacity for D-glucose transport of guinea pig erythrocyte membranes were compared to alterations in the electrophoretic pattern of erythrocyte membrane components. Guinea pig erythrocytes lose their D-glucose carrier functions during development. Good correlation was observed between the loss of glucose uptake and apparent decrease of the zone 4.5 of Coomassie Blue-stained membrane proteins on electrophoresis. Reconstitution of membrane preparations in liposomes resulted in a parallel change in the D-glucose uptake and D-glucose penetration of intact erythrocytes. This suggests that the decrease of D-glucose transport capacity during development is caused by the loss of one or more protein components from the erythrocyte membranes.[1]


  1. Developmental changes in glucose transport of guinea pig erythrocytes. Kondo, T., Beutler, E. J. Clin. Invest. (1980) [Pubmed]
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