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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Intravenous azlocillin kinetics in patients on long-term hemodialysis.

The kinetics of the antipseudomonas penicillin, azlocillin, was studied after intravenous injection in 9 patients with creatinine clearance under 7 ml/min. All were on long-term hemodialysis; 3 were also studied during a dialysis-free period. Kinetic parameters were derived using a 2-compartment open model. The mean serum azlocillin half-life (t 1/2) was 1.93 hr in patients on dialysis and approximately 5 hr off dialysis. Thirty percent of the dose was recovered in the dialysate during a 4-hr period. An approach to the use of azlocillin in patients undergoing dialysis is presented.[1]

References

  1. Intravenous azlocillin kinetics in patients on long-term hemodialysis. Aletta, J.M., Francke, E.F., Neu, H.C. Clin. Pharmacol. Ther. (1980) [Pubmed]
 
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