Nonlinear current-voltage relationships in cultured macrophages.
Intracellular recordings of cultured mouse thioglycolate-induced peritoneal exudate macrophages reveal that these cells can exhibit two different types of electrophysiological properties characterized by differences in their current-voltage relationships and their resting membrane potentials. The majority of cells had low resting membrane potentials (-20 to -40 mV) and displayed current-voltage relationships that were linear for inward-going current pulses and rectifying for outward-going pulses. Small depolarizing transients, occurring either spontaneously or induced by current pulses, were seen in some cells with low resting membrane potentials. A second smaller group of cells exhibited more hyperpolarized resting membrane potentials (-60 to -90 mV) and S-shaped current-voltage relationships associated with a high-resistance transitional region. Cells with S-shaped current-voltage relationships sometimes exhibited two stable states of membrane potential on either side of the high-resistance transitional region. These data indicate that macrophages exhibit complex electrophysiological properties often associated with excitable cells.[1]References
- Nonlinear current-voltage relationships in cultured macrophages. Gallin, E.K., Livengood, D.R. J. Cell Biol. (1980) [Pubmed]
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