The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Relationships of S-phase fraction of breast carcinoma in relapse to duration of remission, estrogen receptor content, therapeutic responsiveness, and duration of survival.

The fractions of tumor cells in S phase (DNA synthesis) were measured by in vitro thymidine labeling and autoradiography in 48 breast carcinomas after relapse. The S-phase fractions (SPF's), expressed as S-phase cells/100 cells, had a lognormal distribution with a geometric mean of 6.5 and a median of 7. 4. Paired SPF measurements on the primary and relapsed breast carcinomas of 14 patients showed that the SPF usually increased over time. The SPF after relapse correlated negatively with the interval between primary therapy and relapse and with duration of survival after relapse. Low SPF's were associated with older age, minimal nuclear anaplasia, and estrogen receptor positivity, but SPF was the only variable that could be shown to have independent prognostic significance. Therefore, the prognostic powers of the estrogen receptor status and nuclear grade appear to result from their correlations with the SPF. Either low SPF or presence of estrogen receptor predicted response to hormonal therapy.[1]

References

 
WikiGenes - Universities