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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Transitional states of the neuronal serotonergic site.

Binding of [3H]5-HT was studied using purified neuronal membranes isolated from horse brain striatum. It is shown that the preincubation of these membranes with an agonist (5-HT, bufotenin) followed by washing, modified the binding of [3H]5-HT from a low affinity to a high affinity constant. This effect was blocked by previous pretreatment of the membranes with a sulfhydryl group reagent (N-ethylmaleimide) and was reversed by guanoside 5'-triphosphate.[1]


  1. Transitional states of the neuronal serotonergic site. Fillion, G., Fillion, M.P. Eur. J. Pharmacol. (1980) [Pubmed]
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